Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736615 | 0.92 | — | — | |
| SCHEMBL9736662 | 0.91 | DRD3 (0.34) | DRD3OPRD1 | |
| SCHEMBL9736903 | 0.91 | OPRD1 (0.34) | OPRM1OPRD1 | |
| SCHEMBL9736930 | 0.84 | MEN1 (0.32) | — | |
| SCHEMBL9197783 | 0.82 | ABCB1 (0.34) | DRD3DRD2 | |
| SCHEMBL9195508 | 0.77 | F10 (0.34) | OPRM1DRD3DRD2OPRK1F10 | |
| SCHEMBL9738250 | 0.77 | OPRM1 (0.36) | OPRM1DRD3DRD2OPRK1OPRD1 | |
| SCHEMBL9198396 | 0.72 | ABCC9 (0.39) | DRD3DRD2 | |
| SCHEMBL9735028 | 0.72 | ABCC9 (0.37) | DRD3DRD2 | |
| SCHEMBL9735367 | 0.72 | ALOX15 (0.38) | OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |