Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737011 | 0.86 | PNMT (0.34) | ALDH1A1 | |
| SCHEMBL9735728 | 0.86 | CYP11B2 (0.33) | BACE1CYP11B2 | |
| SCHEMBL9736155 | 0.72 | XIAP (0.32) | BACE1MEN1ALDH1A1KMT2A | |
| SCHEMBL9735247 | 0.71 | ABCC9 (0.34) | BACE1MEN1ALDH1A1KMT2A | |
| SCHEMBL9736930 | 0.71 | MEN1 (0.32) | BACE1MEN1ALDH1A1KMT2A | |
| SCHEMBL9735711 | 0.70 | ALDH1A1 (0.31) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7890094 | 0.58 | BACE1 (0.43) | BACE1 | |
| SCHEMBL12317890 | 0.57 | BACE1 (0.45) | BACE1 | |
| SCHEMBL9733411 | 0.56 | OPRM1 (0.38) | MEN1ALDH1A1KMT2A | |
| SCHEMBL26759016 | 0.56 | MEN1 (0.34) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |