SCHEMBL9737626

SCHEMBL9737626

CNC(=O)Cc1c(-c2ccccc2)nn2cccnc12

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 7/20 0.45
KCNQ2 O43526 7/20 0.45
HTR6 P50406 1/20 0.42
ALDH1A1 P00352 2/20 0.40
APOBEC3A P31941 1/20 0.40
IRAK4 Q9NWZ3 1/20 0.39
HPGD P15428 2/20 0.39
KDM4E B2RXH2 1/20 0.39
PTGS2 P35354 1/20 0.38
MYC P01106 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.37
NR4A2 P43354 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9737185 0.91 KCNQ3 (0.41) KCNQ3KCNQ2ALDH1A1IRAK4HPGD
SCHEMBL9738434 0.90 KCNQ3 (0.41) KCNQ3KCNQ2HTR6ALDH1A1APOBEC3A
SCHEMBL9737699 0.86 PTGDR2 (0.46) KCNQ3KCNQ2ALDH1A1APOBEC3AIRAK4
SCHEMBL9738233 0.84 KCNQ3 (0.43) KCNQ3KCNQ2HTR6ALDH1A1APOBEC3A
SCHEMBL9738747 0.83 ALDH1A1 (0.45) KCNQ3KCNQ2ALDH1A1APOBEC3APTGS2
SCHEMBL9737130 0.81 L3MBTL1 (0.48) ALDH1A1HPGDKDM4E
SCHEMBL18116342 0.81 HTR1B (0.44)
SCHEMBL9737796 0.79 GABRA2 (0.47)
SCHEMBL9737283 0.79 PTGDR2 (0.47) ALDH1A1APOBEC3AKDM4EPTGS2MYC
SCHEMBL9737634 0.77 KDM4E (0.48) ALDH1A1APOBEC3AHPGDKDM4EPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5114944-A Anxiolytic and anticonvulsant agents; muscle relaxants A. H. ROBINS COMPANY INCORPORATED (US) 1992-05-19 US claimed
US-5114944-A Anxiolytic and anticonvulsant agents; muscle relaxants A. H. ROBINS COMPANY INCORPORATED (US) 1992-05-19 US disclosed