Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9744143 | 0.90 | HSD17B10 (0.45) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| Potassium SCHEMBL9744154 | 0.90 | HSD17B10 (0.45) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL21937028 | 0.73 | MAPT (0.51) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL30306133 | 0.72 | HSD17B10 (0.75) | ALDH1A1KDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL4768364 | 0.72 | HSD17B10 (0.75) | ALDH1A1KDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL9743791 | 0.71 | DRD3 (0.45) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL9743778 | 0.71 | DRD3 (0.45) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL9302272 | 0.71 | MAPT (0.42) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL9633140 | 0.71 | KDM4E (0.63) | ALDH1A1KDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL9302880 | 0.70 | HTT (0.46) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147871-A | Anti-bacterial cephalosporin compounds | HOFFMANN LA-ROCHE, INC. (US) | 1992-09-15 | — | — | US | disclosed |