Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757007 | 0.88 | CYP4F2 (0.40) | ELANECYP1A2PLK1MTNR1AMTNR1B | |
| SCHEMBL31745175 | 0.84 | CYP1A2 (0.46) | CYP1A2PLK1MEN1KMT2AKDM4E | |
| SCHEMBL9757020 | 0.83 | FAAH (0.53) | ELANECYP1A2MEN1KMT2AKDM4E | |
| SCHEMBL9757062 | 0.82 | MAOA (0.54) | CYP1A2MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL14897791 | 0.81 | ALDH1A1 (0.48) | CYP1A2POLBMEN1KMT2AKDM4E | |
| SCHEMBL31745296 | 0.80 | DHODH (0.50) | CYP1A2POLBMEN1KMT2AKDM4E | |
| SCHEMBL9756985 | 0.79 | PLK1 (0.46) | ELANECYP1A2PLK1KMT2AKDM4E | |
| SCHEMBL9757218 | 0.77 | ALDH1A1 (0.43) | CYP1A2POLBKDM4ELMNASMN1; SMN2 | |
| SCHEMBL29728162 | 0.76 | KDM4E (0.50) | CYP1A2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL38654913 | 0.75 | TRPM8 (0.44) | CYP1A2MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |