Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | IGFBP3 | P17936 | 4/20 | 0.41 |
| ▸ | IGFBP5 | P24593 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | IGFBP1 | P08833 | 1/20 | 0.41 |
| ▸ | IGFBP2 | P18065 | 1/20 | 0.41 |
| ▸ | IGFBP4 | P22692 | 1/20 | 0.41 |
| ▸ | IGFBP6 | P24592 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SELL | P14151 | 1/20 | 0.38 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595216 | 0.85 | KDM4E (0.49) | KDM4ETDP1MAPTRAB9AKMT2A | |
| SCHEMBL6080950 | 0.81 | KDM4E (0.46) | KDM4ETDP1MAPTRAB9AKMT2A | |
| Xanthurenate SCHEMBL379760 | 0.79 | KDM4E (0.59) | KDM4ETDP1MAPTRAB9AKMT2A | |
| Xanthurenate SCHEMBL29394132 | 0.79 | KDM4E (0.59) | KDM4ETDP1MAPTRAB9AKMT2A | |
| Xanthurenate SCHEMBL29911018 | 0.79 | KDM4E (0.59) | KDM4ETDP1MAPTRAB9AKMT2A | |
| SCHEMBL6080062 | 0.78 | KDM4E (0.43) | KDM4ETDP1MAPTRAB9AKMT2A | |
| SCHEMBL351902 | 0.77 | GPR35 (0.46) | KDM4ETDP1MAPTRAB9AKMT2A | |
| SCHEMBL29450080 | 0.77 | GPR35 (0.46) | KDM4ETDP1MAPTRAB9AKMT2A | |
| SCHEMBL6080733 | 0.77 | KDM4E (0.43) | KDM4ETDP1MAPTRAB9ALCK | |
| SCHEMBL13313445 | 0.76 | ALOX15 (0.52) | KDM4ETDP1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12076316-B2 | Levorphanol prodrugs and processes for making and using them | ZEVRA THERAPEUTICS INC. | 2024-09-03 | — | — | US | claimed |
| US-20220096463-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2022-03-31 | — | — | US | claimed |
| US-11234975-B2 | Levorphanol prodrugs and processes for making and using them | KEMPHARM, INC. (US) | 2022-02-01 | — | — | US | claimed |
| US-20200390757-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2020-12-17 | — | — | US | claimed |
| WO-2018191474-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | KEMPHARM, INC. (US) | 2018-10-18 | — | — | WO | claimed |
| US-20170312270-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2017-11-02 | — | — | US | claimed |
| CN-107261148-A | Methylphenidate prodrug, its preparation and application | 凯姆制药公司 | 2017-10-20 | — | — | CN | claimed |
| EP-3226907-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF | Kempharm, Inc. (US) | 2017-10-11 | — | — | EP | claimed |
| EP-3223819-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE | Kempharm, Inc. (US) | 2017-10-04 | — | — | EP | claimed |
| CN-106999487-A | Benzoic acid conjugate, benzoic acid derivative conjugate and the heteroaryl carboxylic acid conjugate of Oxymorphone, its prodrug, preparation and application | 凯姆制药公司 | 2017-08-01 | — | — | CN | claimed |
| WO-2016089951-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF | KEMPHARM, INC. (US) | 2016-06-09 | — | — | WO | claimed |
| US-20160151352-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2016-06-02 | — | — | US | claimed |
| WO-2016086113-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE | KEMPHARM, INC. (US) | 2016-06-02 | — | — | WO | claimed |
| CN-104136031-A | Benzoic acid, benzoic acid derivative and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and using thereof | KEMPHARM INC | 2014-11-05 | — | — | CN | claimed |
| EP-2771002-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | Kempharm, Inc. (US) | 2014-09-03 | — | — | EP | claimed |
| EP-2736510-A2 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2014-06-04 | — | — | EP | claimed |
| CN-103826633-A | Methylphenidate prodrugs, methods of making and using the same | KEMPHARM INC | 2014-05-28 | — | — | CN | claimed |
| US-20130150395-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | KEMPHARM, INC. (US) | 2013-06-13 | — | — | US | claimed |
| WO-2013063204-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | KEMPHARM, INC. (US) | 2013-05-02 | — | — | WO | claimed |
| WO-2013016668-A2 | METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME | KEMPHARM INC. (US) | 2013-01-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390757-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | OPRM1, OPRL1, OPRK1 | KDM4E 2657/4885TDP1 1241/4885MAPT 2539/4885 |
| US-20170312270-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | OPRM1, OPRK1, OPRD1 | KDM4E 2523/4885TDP1 828/4885MAPT 2959/4885 |
| US-20160151352-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | OPRM1, OPRK1, OPRD1 | KDM4E 2523/4885TDP1 828/4885MAPT 2959/4885 |
| US-12076316-B2 | Levorphanol prodrugs and processes for making and using them | OPRM1, OPRL1, OPRK1 | KDM4E 2657/4885TDP1 1241/4885MAPT 2539/4885 |
| US-11234975-B2 | Levorphanol prodrugs and processes for making and using them | OPRM1, OPRL1, OPRK1 | KDM4E 2657/4885TDP1 1241/4885MAPT 2539/4885 |
| US-20130150395-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | OPRM1, OPRK1, CYP2D6 | KDM4E 3324/4885TDP1 1353/4885MAPT 1933/4885 |
| US-20220096463-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | OPRM1, OPRL1, OPRK1 | KDM4E 2657/4885TDP1 1241/4885MAPT 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.