Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324941 | 0.93 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL9509519 | 0.83 | MAPT (0.48) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL12181771 | 0.79 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL3943393 | 0.78 | MAPT (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL9760352 | 0.78 | LMNA (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL8640682 | 0.78 | LMNA (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL3743073 | 0.77 | ALDH1A1 (0.44) | MAPTHTTALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL18392174 | 0.75 | HTT (0.88) | MAPTHTTLMNAALDH1A1KDM4E | |
| SCHEMBL9554998 | 0.74 | LTA4H (0.49) | MAPTHTTLMNAALDH1A1CYP2C9 | |
| SCHEMBL10967156 | 0.72 | LMNA (0.62) | MAPTHTTLMNAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009485-A1 | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis | WYETH (US) | 2008-01-10 | — | — | US | disclosed |
| US-4986935-A | NONLINEAR OPTICAL DEVICES; COMPOUND HAVING HIGH ACTIVITY FOR SECOND HARMONIC WAVE GENERATION | FUJI XEROX CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| US-4751327-A | Photoconductive imaging members with unsymmetrical squaraine compounds | XEROX CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |
| US-4624904-A | Photoconductive imaging members with unsymmetrical squaraine compounds containing an hydroxyl group | XEROX CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009485-A1 | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis | PLA2G12A, PLA2G1B, PLA2G5 | PDE4B 220/4885PDE4A 238/4885PDE4C 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.