Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9293066 | 0.88 | KMT2A (0.46) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL23003615 | 0.84 | KCNN4 (0.50) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL20312568 | 0.82 | MEN1 (0.48) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL1421745 | 0.82 | APP (0.49) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL22937461 | 0.80 | RAB9A (0.47) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL11286874 | 0.80 | KMT2A (0.47) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL2634475 | 0.80 | KCNN4 (0.63) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL13427572 | 0.79 | KCNN4 (0.61) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL1107165 | 0.79 | TSHR (0.50) | KMT2AMAPTMEN1SMN1; SMN2RAB9A | |
| SCHEMBL13313605 | 0.79 | ESR1 (0.54) | KMT2AMAPTMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160106742-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS, INC. | 2016-04-21 | — | — | US | disclosed |
| US-7868036-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-01-11 | — | — | US | disclosed |
| US-20080058320-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-03-06 | — | — | US | disclosed |
| US-20070066582-A1 | Diaminoalcohols as therapeutic compounds | SPEEDEL EXPERIMENTA AG (CH) | 2007-03-22 | — | — | US | disclosed |
| US-5030625-A | Applying to phytopathogen | SANDOZ LTD. (CH) | 1991-07-09 | — | — | US | disclosed |
| EP-0191269-B1 | NOVEL HOMOPROPARGYLAMINES | SANDOZ AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| US-4684661-A | Anti-fungal homopropargylamines, compositions, and method of use therefor | SANDOZ LTD. (CH) | 1987-08-04 | — | — | US | disclosed |
| EP-0191269-A2 | Novel homopropargylamines | SANDOZ AG (CH) | 1986-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160106742-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | PCK1, PDK3, PDK2 | KMT2A 1401/4885MAPT 3114/4885MEN1 3741/4885 |
| US-20070066582-A1 | Diaminoalcohols as therapeutic compounds | CTSD, CTSL, CTSC | KMT2A 3003/4885MAPT 454/4885MEN1 2326/4885 |
| US-20080058320-A1 | Organic Compounds | REN, AGTR1, ADH1C | KMT2A 3647/4885MAPT 1300/4885MEN1 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.