Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770572 | 0.91 | KMT2A (0.44) | LMNAACHEKMT2AMAPK1MEN1 | |
| SCHEMBL9770495 | 0.84 | KDM4E (0.44) | LMNAACHEALDH1A1ELANEMAPT | |
| SCHEMBL9770632 | 0.84 | KDM4E (0.44) | LMNAACHEALDH1A1ELANEMAPT | |
| SCHEMBL9770634 | 0.75 | LMNA (0.53) | LMNAACHEALDH1A1KMT2AMAPK1 | |
| SCHEMBL9770631 | 0.74 | GAA (0.46) | LMNAACHEALDH1A1KMT2AMEN1 | |
| SCHEMBL9770560 | 0.72 | ALDH1A1 (0.54) | LMNAALDH1A1KMT2AMAPK1MEN1 | |
| SCHEMBL9770534 | 0.70 | LMNA (0.47) | LMNAALDH1A1KMT2AMAPK1MEN1 | |
| SCHEMBL9770553 | 0.70 | LMNA (0.51) | LMNAALDH1A1KMT2AMAPK1MEN1 | |
| SCHEMBL9770600 | 0.67 | LMNA (0.60) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9770640 | 0.66 | CTSB (0.54) | LMNAALDH1A1KMT2AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019574-A | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-05-28 | — | — | US | disclosed |
| EP-0361489-A2 | Novel 3,4-diaminoquinoline and pyridine compounds | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-04-04 | — | — | EP | disclosed |