Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | FDPS | P14324 | 4/20 | 0.53 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401437 | 0.81 | FDPS (0.47) | FDPSFDFT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9819252 | 0.78 | FDPS (0.47) | FDPSFDFT1MAPTCA12CA1 | |
| SCHEMBL9819343 | 0.76 | RAB9A (0.49) | FDPSFDFT1MAPTNPC1RAB9A | |
| SCHEMBL9819305 | 0.76 | FDPS (0.47) | FDPSFDFT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9819397 | 0.75 | PPARA (0.47) | FDPSFDFT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9819210 | 0.73 | NPC1 (0.46) | FDPSNPC1RAB9ATSHR | |
| SCHEMBL9819301 | 0.73 | FDPS (0.41) | FDPSFDFT1RAB9AALDH1A1 | |
| SCHEMBL9819288 | 0.73 | FDPS (0.51) | FDPSFDFT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL149194 | 0.73 | TRPM8 (0.70) | TRPM8MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9819238 | 0.72 | FDPS (0.57) | FDPSFDFT1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282320-B1 | BISPHOSPHONIC ACID DERIVATIVES AND MEDICINES CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-12-11 | — | — | EP | claimed |
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| EP-0282320-A1 | Bisphosphonic acid derivatives and medicines containing the same | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | claimed |
| JP-2000185-A | — | — | None | — | — | JP | disclosed |
| EP-0282320-B1 | BISPHOSPHONIC ACID DERIVATIVES AND MEDICINES CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| US-4973576-A | ANTIARTHRITIC AGENTS, TREATMENT OF HYPERCALCEMIA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-11-27 | — | — | US | disclosed |
| JP-H02185-A | BISPHOSPHONIC ACID DERIVATIVE AND MEDICINE THEREOF | YAMANOUCHI PHARMACEUT CO LTD | 1990-01-05 | — | — | JP | disclosed |
| EP-0282320-A1 | Bisphosphonic acid derivatives and medicines containing the same | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | disclosed |