Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK known ✓ | Q06187 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795290 | 0.92 | ALDH1A1 (0.37) | MAOASMN1; SMN2NPC1GAABCHE | |
| Fumaric Acid SCHEMBL9795108 | 0.88 | POLB (0.37) | POLBSMN1; SMN2HTTNPC1GAA | |
| Fumaric Acid SCHEMBL9795089 | 0.83 | POLB (0.41) | POLBSMN1; SMN2HTTNPC1GAA | |
| Fumaric Acid SCHEMBL9795178 | 0.81 | SMYD3 (0.41) | POLB | |
| SCHEMBL9019551 | 0.80 | POLB (0.64) | POLBSMN1; SMN2HTTNPC1GAA | |
| SCHEMBL9498706 | 0.79 | SMYD3 (0.37) | POLBSMN1; SMN2BCHEL3MBTL1ALDH1A1 | |
| SCHEMBL9501486 | 0.79 | SMYD3 (0.37) | POLBSMN1; SMN2BCHEL3MBTL1ALDH1A1 | |
| SCHEMBL9795170 | 0.79 | SMYD3 (0.37) | POLBSMN1; SMN2BCHEL3MBTL1ALDH1A1 | |
| SCHEMBL9019581 | 0.77 | ALDH1A1 (0.39) | SMN1; SMN2BCHEL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL9137074 | 0.76 | SMYD3 (0.37) | SMN1; SMN2BCHEL3MBTL1ALDH1A1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |