Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795527 | 0.92 | SMYD3 (0.44) | SMYD3 | |
| SCHEMBL9497857 | 0.92 | SMYD3 (0.44) | SMYD3 | |
| SCHEMBL9497980 | 0.92 | SMYD3 (0.44) | SMYD3 | |
| Fumaric Acid SCHEMBL9795089 | 0.90 | POLB (0.41) | SMYD3POLB | |
| Fumaric Acid SCHEMBL9795108 | 0.84 | POLB (0.37) | SMYD3POLB | |
| Fumaric Acid SCHEMBL9795135 | 0.81 | POLB (0.39) | POLB | |
| SCHEMBL9019551 | 0.81 | POLB (0.64) | POLB | |
| SCHEMBL9795195 | 0.81 | ALDH1A1 (0.39) | SMYD3 | |
| SCHEMBL9126469 | 0.80 | SMYD3 (0.39) | SMYD3POLB | |
| SCHEMBL9019562 | 0.77 | SMN1; SMN2 (0.45) | SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |