Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.33 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795256 | 0.93 | HSD11B1 (0.45) | HSD11B1L3MBTL1TP53ADORA2AADORA1 | |
| Fumaric Acid SCHEMBL9795509 | 0.88 | POLB (0.43) | HSD11B1TP53KMT2APOLBBCHE | |
| Fumaric Acid SCHEMBL9795497 | 0.84 | KMT2A (0.33) | KMT2ABCHESMN1; SMN2PKMTAAR1 | |
| Fumaric Acid SCHEMBL9795270 | 0.82 | GNAI3 (0.34) | KMT2AHTTBCHELMNATSHR | |
| SCHEMBL9795239 | 0.80 | POLB (0.48) | HSD11B1TP53KMT2APOLBBCHE | |
| Fumaric Acid SCHEMBL9795211 | 0.79 | ALOX15 (0.43) | L3MBTL1POLBSMN1; SMN2TSHRALDH1A1 | |
| Fumaric Acid SCHEMBL9795305 | 0.79 | SMN1; SMN2 (0.38) | KMT2AHSD17B10SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9795340 | 0.78 | ALDH1A1 (0.43) | L3MBTL1KMT2APOLBSMN1; SMN2TSHR | |
| SCHEMBL9127574 | 0.78 | KMT2A (0.34) | KMT2AHSD17B10BCHEPKMTAAR1 | |
| Fumaric Acid SCHEMBL9795180 | 0.77 | SMN1; SMN2 (0.42) | HSD17B10SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |