Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795555 | 0.84 | POLB (0.38) | CYP3A4ALDH1A1POLB | |
| SCHEMBL9795628 | 0.83 | SIGMAR1 (0.45) | CYP2C19ALOX15SIGMAR1TSHR | |
| SCHEMBL11573258 | 0.82 | TDP1 (0.40) | ALDH1A1RAB9AHTTNPC1POLB | |
| SCHEMBL9795800 | 0.81 | SIGMAR1 (0.38) | CYP2C19ALDH1A1ALOX15SIGMAR1SMN1; SMN2 | |
| SCHEMBL9796050 | 0.79 | MAOB (0.50) | ALDH1A1LMNA | |
| SCHEMBL9795705 | 0.77 | MAOA (0.38) | ALDH1A1HSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL9135583 | 0.77 | RAB9A (0.50) | ALDH1A1HSD17B10RAB9AHTTNPC1 | |
| SCHEMBL9779999 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HSD17B10RAB9AHTTNPC1 | |
| SCHEMBL2808762 | 0.76 | ALDH1A1 (0.48) | CYP3A4CYP2C9CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL13645027 | 0.76 | ALOX15 (0.46) | CYP3A4CYP2C9CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023255-A | Triazine derivatives; inhibitors exzyme 5-lipoxygenase | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0388165-A2 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 1990-09-19 | — | — | EP | disclosed |