Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrogallol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.67 |
| ▸ | CA2 | P00918 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | CA6 | P23280 | 2/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | FYN | P06241 | 1/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | CDK2 | P24941 | 1/20 | 0.67 |
| ▸ | MMP12 | P39900 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrogallol SCHEMBL8433563 | 1.00 | CA1 (0.67) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL225781 | 0.92 | CA1 (0.71) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL6984242 | 0.88 | CA2 (0.75) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL10407842 | 0.85 | ALDH1A1 (0.55) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL4947548 | 0.85 | ALDH1A1 (0.55) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Acetic Acid SCHEMBL4221099 | 0.85 | TRPA1 (0.77) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Acetophenone SCHEMBL8429481 | 0.84 | MAPT (0.54) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Catechol SCHEMBL2707627 | 0.82 | CA2 (0.62) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Catechol SCHEMBL8411371 | 0.82 | CA2 (0.62) | CA1CA2ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL10717987 | 0.82 | ALDH1A1 (0.57) | CA1CA2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119744184-A | Mussel inspired tissue adhesives and methods of use thereof | 普渡研究基金会 | 2025-04-01 | — | — | CN | claimed |
| CN-104341307-A | Phenylacetic acid derivative and anti-tumor application thereof | PHARMACEUTICAL RES & DEV CORP OF JINGPENGHUI | 2015-02-11 | — | — | CN | claimed |
| CN-119744184-A | Mussel inspired tissue adhesives and methods of use thereof | 普渡研究基金会 | 2025-04-01 | — | — | CN | disclosed |
| CN-113945674-B | Characteristic spectrum and analysis method of processed rehmannia root product | 江西省药品检验检测研究院（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-113945674-A | Characteristic spectrum and analysis method of processed rehmannia root product | 江西省药品检验检测研究院 | 2022-01-18 | — | — | CN | disclosed |
| EP-2709977-B1 | USE OF BENZOTROPOLONE DERIVATIVES AS PHOTOSTABILIZER AND ANTIOXIDANT FOR STABILIZATION OF BODY-CARE AND HOUSEHOLD PRODUCTS. | BASF SE (DE) | 2018-09-05 | — | — | EP | disclosed |
| CN-108383721-A | A kind of synthetic method of medicine intermediate oxyhydroquinone acetate | 新沂市中诺新材料科技有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-104606186-B | Application of the hydroxy coumarin compound of fluoro 7 in kinases inhibitor or/and antineoplastic | 北京工业大学 | 2017-09-12 | — | — | CN | disclosed |
| US-9663442-B2 | Stabilization of household, body-care and food products by using benzotropolone containing plant extracts and/or related benzotropolone derivatives | BASF SE (DE) | 2017-05-30 | — | — | US | disclosed |
| CN-104341307-B | Phenylacetic acid derivatives and anticancer usage thereof | 北京京朋汇药业研究发展有限公司 | 2016-12-28 | — | — | CN | disclosed |
| US-20150353470-A1 | STABILIZATION OF HOUSEHOLD, BODY-CARE AND FOOD PRODUCTS BY USING BENZOTROPOLONE CONTAINING PLANT EXTRACTS AND/OR RELATED BENZOTROPOLONE DERIVATIVES | BASF SE (DE) | 2015-12-10 | — | — | US | disclosed |
| CN-104341307-A | Phenylacetic acid derivative and anti-tumor application thereof | PHARMACEUTICAL RES & DEV CORP OF JINGPENGHUI | 2015-02-11 | — | — | CN | disclosed |
| US-8784853-B2 | Stabilization of household, body-care and food products by using benzotropolone containing plant extracts and/or related benzotropolone derivatives | BASF SE (DE) | 2014-07-22 | — | — | US | disclosed |
| EP-2709977-A2 | USE OF BENZOTROPOLONE DERIVATIVES AS PHOTOSTABILIZER AND ANTIOXIDANT FOR STABILIZATION OF BODY-CARE AND HOUSEHOLD PRODUCTS. | BASF SE (DE) | 2014-03-26 | — | — | EP | disclosed |
| CN-102858916-A | Stabilization of household, body-care and food products by using benzotropolone containing plant extracts and/or related benzotropolone derivatives | BASF SE | 2013-01-02 | — | — | CN | disclosed |
| US-20120230925-A1 | STABILIZATION OF HOUSEHOLD, BODY-CARE AND FOOD PRODUCTS BY USING BENZOTROPOLONE CONTAINING PLANT EXTRACTS AND/OR RELATED BENZOTROPOLONE DERIVATIVES | BASF SE (DE) | 2012-09-13 | — | — | US | disclosed |
| US-5071929-A | A malemide, a naphthalene-vinylbenzyl ether, and a benzene vinyl benzyl ether; low temperature curing; heat resistance, mechamical strength; molding materials | SHOWA HIGHPOLYMER CO., LTD. (JP) | 1991-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120230925-A1 | STABILIZATION OF HOUSEHOLD, BODY-CARE AND FOOD PRODUCTS BY USING BENZOTROPOLONE CONTAINING PLANT EXTRACTS AND/OR RELATED BENZOTROPOLONE DERIVATIVES | CBR3, CBR1, CYP8B1 | CA1 4566/4885CA2 3802/4885ALDH1A1 2680/4885 |
| US-20150353470-A1 | STABILIZATION OF HOUSEHOLD, BODY-CARE AND FOOD PRODUCTS BY USING BENZOTROPOLONE CONTAINING PLANT EXTRACTS AND/OR RELATED BENZOTROPOLONE DERIVATIVES | CBR3, CBR1, CYP8B1 | CA1 4565/4885CA2 3875/4885ALDH1A1 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.