Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64274 | 0.81 | TDP1 (0.52) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL9825190 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL11240709 | 0.80 | TSHR (0.48) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL2146344 | 0.77 | TDP1 (0.48) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL11322544 | 0.77 | TDP1 (0.48) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| Zinc Ion SCHEMBL23062763 | 0.76 | ALDH1A1 (0.41) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL5574638 | 0.75 | TSHR (0.52) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| SCHEMBL30629348 | 0.75 | TDP1 (0.48) | ALDH1A1TSHRTDP1L3MBTL1MAPT | |
| Potassium Ion SCHEMBL9176552 | 0.75 | CA12 (0.44) | L3MBTL1MAPTPOLBRECQLCA12 | |
| SCHEMBL9720219 | 0.74 | TSHR (0.44) | ALDH1A1TSHRTDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217747-B1 | NEMATOCIDAL AGENTS | CIBA-GEIGY AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| US-4694014-A | 1,3,4-THIADIAZOLES | CIBA-GEIGY CORPORATION (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0217747-A2 | Nematocidal agents | CIBA-GEIGY AG (CH) | 1987-04-08 | — | — | EP | disclosed |