Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 14/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363437 | 0.92 | TBXA2R (0.58) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9363708 | 0.88 | TBXA2R (0.60) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9452838 | 0.88 | TBXA2R (0.83) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9835158 | 0.86 | TBXA2R (0.54) | TBXA2RHDAC8 | |
| SCHEMBL9472212 | 0.84 | TBXA2R (0.68) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9472370 | 0.82 | TBXA2R (0.64) | TBXA2RHDAC8 | |
| SCHEMBL9364007 | 0.82 | TBXA2R (0.69) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9472408 | 0.82 | TBXA2R (0.67) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9471897 | 0.81 | TBXA2R (0.66) | TBXA2RHDAC8TBXAS1 | |
| SCHEMBL9472260 | 0.81 | TBXA2R (0.70) | TBXA2RHDAC8TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430459-A1 | Tetrahydronaphthalene derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |