Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602580 | 0.82 | MCHR1 (0.39) | MCHR1TOP1PDE4APDE4BPDE4C | |
| SCHEMBL9865071 | 0.80 | MCHR1 (0.38) | MCHR1TOP1PDE4APDE4BPDE4C | |
| SCHEMBL10558921 | 0.77 | GABRP (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL9602777 | 0.77 | MCHR1 (0.35) | MCHR1TOP1 | |
| SCHEMBL9865971 | 0.74 | MCHR1 (0.35) | MCHR1TOP1 | |
| SCHEMBL9602772 | 0.74 | MCHR1 (0.35) | MCHR1TOP1 | |
| SCHEMBL9603147 | 0.74 | MCHR1 (0.35) | MCHR1TOP1KMT2A | |
| SCHEMBL9866052 | 0.73 | MCHR1 (0.34) | MCHR1TOP1KMT2A | |
| SCHEMBL9868430 | 0.73 | TOP1 (0.35) | MCHR1TOP1KMT2A | |
| SCHEMBL9602906 | 0.73 | MCHR1 (0.35) | MCHR1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |