Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10394269 | 0.89 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2APLNRCYP1A2PDE2A | |
| SCHEMBL2704089 | 0.81 | L3MBTL1 (0.48) | L3MBTL1SMN1; SMN2LMNACYP1A2PDE2A | |
| SCHEMBL10509802 | 0.74 | APLNR (0.35) | APLNRALDH1A1MIF | |
| SCHEMBL9517836 | 0.73 | L3MBTL1 (0.41) | L3MBTL1SMN1; SMN2LMNAAPLNRCYP1A2 | |
| SCHEMBL28377189 | 0.71 | L3MBTL1 (0.52) | L3MBTL1SMN1; SMN2LMNACYP1A2PDE2A | |
| SCHEMBL10394994 | 0.71 | POLB (0.37) | LMNACYP1A2ALDH1A1KDM4EMIF | |
| SCHEMBL484216 | 0.71 | MIF (0.35) | CYP1A2ALDH1A1MIFTDP1HPGD | |
| SCHEMBL10647845 | 0.70 | L3MBTL1 (0.50) | L3MBTL1SMN1; SMN2LMNACYP1A2PDE2A | |
| SCHEMBL8446835 | 0.69 | GAA (0.43) | L3MBTL1SMN1; SMN2LMNACYP1A2ALDH1A1 | |
| SCHEMBL5573217 | 0.69 | GABRP (0.33) | CYP1A2ALDH1A1MIFTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541802-B1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2025-01-01 | — | — | EP | disclosed |
| US-11046680-B1 | Heteroaryl-substituted triazoles as APJ receptor agonists | AMGEN INC. (US) | 2021-06-29 | — | — | US | disclosed |
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-3541804-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093577-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |
| US-9868721-B2 | Triazole agonists of the APJ receptor | AMGEN INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9656998-B2 | Intermediates for preparing triazole agonists of the APJ receptor | AMGEN INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20170042897-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC. | 2017-02-16 | — | — | US | disclosed |
| US-20170037026-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC. | 2017-02-09 | — | — | US | disclosed |
| US-5069709-A | PRE-AND POSTEMERGENCE; PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| CN-1041592-A | Sultamsulfonamide derivatives and weedicide | NISSAN CHEMICAL IND LTD (JP) | 1990-04-25 | — | — | CN | disclosed |
| US-4897105-A | (1,2,4)-THIADIAZOLO(2,3-A)PYRIMIDINE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0342456-A2 | Sultamsulfonamide derivatives and herbicides | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-11-23 | — | — | EP | disclosed |
| US-4872901-A | PREFERENTIAL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-10-10 | — | — | US | disclosed |
| CN-87102275-A | Selective herbicide and manufacturing thereof and use | — | 1988-02-17 | — | — | CN | disclosed |
| EP-0239064-A2 | Herbicidal compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-30 | — | — | EP | disclosed |
| EP-0220695-A1 | Herbicidal compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046680-B1 | Heteroaryl-substituted triazoles as APJ receptor agonists | AGTR1, AGTR2, TBXA2R | L3MBTL1 4800/4885SMN1; SMN2 4728/4885LMNA 3334/4885 |
| US-20170037026-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | TBXA2R, AGTR1, AGTR2 | L3MBTL1 4796/4885SMN1; SMN2 4804/4885LMNA 3741/4885 |
| US-20170042897-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | TBXA2R, AGTR1, AGTR2 | L3MBTL1 4796/4885SMN1; SMN2 4804/4885LMNA 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.