Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877927 | 0.85 | KMT2A (0.54) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL9878201 | 0.84 | KAT2B (0.46) | MAPTPOLBPKMKMT2AALDH1A1 | |
| SCHEMBL9877903 | 0.83 | ALDH1A1 (0.59) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL9877841 | 0.81 | L3MBTL1 (0.45) | MAPTPOLBPKMKMT2AALDH1A1 | |
| SCHEMBL9878288 | 0.81 | MAPT (0.61) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL9877920 | 0.77 | CYP19A1 (0.44) | MAPTPOLBPKMALDH1A1LMNA | |
| SCHEMBL27978261 | 0.77 | MAPT (0.75) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL9878326 | 0.76 | ALDH1A1 (0.56) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL9879008 | 0.75 | CYP19A1 (0.42) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3029764 | 0.75 | MAPT (1.00) | MAPTPOLBPKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992589-A | Substituted phenyl hydroxyethyl sulfones, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |