Sugi Predict

Sugi Predict / Compounds / SCHEMBL988490

SCHEMBL988490

SCHEMBL988490

O=C(O)CCCOc1cccc(Br)c1

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.61
▸ KMT2A Q03164 2/20 0.61
▸ MAPT P10636 1/20 0.61
▸ KDM4E B2RXH2 9/20 0.60
▸ LMNA P02545 1/20 0.60
▸ RAB9A P51151 1/20 0.60
▸ MEN1 O00255 1/20 0.57
▸ POLB P06746 1/20 0.55
▸ GAA P10253 1/20 0.55
▸ FFAR1 O14842 2/20 0.54
▸ FFAR4 Q5NUL3 1/20 0.54
▸ TDP1 Q9NUW8 1/20 0.53
▸ PPARG P37231 1/20 0.53
▸ PPARD Q03181 1/20 0.53
▸ MRGPRX4 Q96LA9 1/20 0.52
▸ MAOB P27338 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29676577 1.00 ALDH1A1 (0.61) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL16596174 0.95 ALDH1A1 (0.63) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL16596197 0.94 ALDH1A1 (0.62) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL16596176 0.94 ALDH1A1 (0.62) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL16596171 0.94 ALDH1A1 (0.62) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL3095787 0.92 KDM4E (0.61) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL29584120 0.92 KDM4E (0.61) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL18332925 0.87 ALDH1A1 (0.57) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL12272227 0.83 KDM4E (0.59) ALDH1A1KMT2AMAPTKDM4ELMNA
SCHEMBL29976920 0.83 KDM4E (0.59) ALDH1A1KMT2AMAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240287076-A1 COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE C4 THERAPEUTICS, INC. 2024-08-29 — — US disclosed
EP-4333899-A1 COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE Biogen MA Inc. (US) 2024-03-13 — — EP disclosed
CN-117580592-A Compounds for targeting bruton's tyrosine kinase degradation 渤健马萨诸塞州股份有限公司 2024-02-20 — — CN disclosed
CN-117567453-A Benzazepine analogs as inhibitors of bruton's tyrosine kinase 渤健马萨诸塞州股份有限公司 2024-02-20 — — CN disclosed
EP-3609886-B1 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC (US) 2024-02-07 — — EP disclosed
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase BIOGEN MA INC. (US) 2024-01-02 — — US disclosed
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase BIOGEN MA INC. (US) 2024-01-02 — — US disclosed
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase BIOGEN MA INC. (US) 2024-01-02 — — US disclosed
EP-4249071-A2 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE Biogen MA Inc. (US) 2023-09-27 — — EP disclosed
EP-4249071-A2 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE Biogen MA Inc. (US) 2023-09-27 — — EP disclosed
US-20090202478-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2009-08-13 — — US disclosed
US-7465811-B2 Indoline compounds LABORATOIRES FOURNIER S.A. (FR) 2008-12-16 — — US disclosed
US-20080119465-A1 Novel Indoline Compounds LABORATORIES FOURNIER S.A. (FR) 2008-05-22 — — US disclosed
US-20050277630-A1 Antibacterial agents CHUPAK LOUIS S 2005-12-15 — — US disclosed
EP-1594494-A1 OXAZOLIDINONE DERIVATIVES N-SUBSTITUTED BY A BICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2005-11-16 — — EP disclosed
EP-1594495-A1 OXAZOLIDINONE DERIVATES N-SUBSTITUTED BY A TRICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2005-11-16 — — EP disclosed
US-20040224939-A1 Antibacterial agents CHUPAK LOUIS S (US) 2004-11-11 — — US disclosed
US-20040204421-A1 Certain 1,3-disubstituted isoquinoline derivatives EISAI CO., LTD. 2004-10-14 — — US disclosed
WO-2004069245-A1 OXAZOLIDINONE DERIVATES N-SUBSTITUTED BY A TRICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2004-08-19 — — WO disclosed
WO-2004069244-A1 OXAZOLIDINONE DERIVATIVES N-SUBSTITUTED BY A BICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2004-08-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050277630-A1 Antibacterial agents MRPL21, RPN2, FBL ALDH1A1 637/4885KMT2A 4819/4885MAPT 4424/4885
US-20040224939-A1 Antibacterial agents MRPL21, RPN2, FBL ALDH1A1 637/4885KMT2A 4819/4885MAPT 4424/4885
US-20090202478-A1 Hepatitis C Virus Inhibitors HAVCR2, PYGL, HCCS ALDH1A1 1144/4885KMT2A 4516/4885MAPT 4065/4885
US-20080119465-A1 Novel Indoline Compounds GPR119, INSR, IRS1 ALDH1A1 1819/4885KMT2A 1435/4885MAPT 763/4885
US-20240287076-A1 COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE BTK, SYK, LYN ALDH1A1 3476/4885KMT2A 872/4885MAPT 1957/4885
US-20040204421-A1 Certain 1,3-disubstituted isoquinoline derivatives MUSK, HTR1A, RYR1 ALDH1A1 1071/4885KMT2A 1300/4885MAPT 3756/4885
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase ABL1, BTK, LYN ALDH1A1 3214/4885KMT2A 1735/4885MAPT 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.