Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21164304 | 0.84 | ALDH1A1 (0.43) | RXFP1IDO1LMNATSHRPOLB | |
| SCHEMBL25063097 | 0.83 | CYP2C19 (0.49) | LMNATSHRPOLBKMT2AKDM4E | |
| SCHEMBL25063427 | 0.83 | ADRA1A (0.41) | TSHRPOLBADRA1AADRA1BKMT2A | |
| SCHEMBL18890276 | 0.82 | RXFP1 (0.41) | RXFP1IDO1LMNATSHRPOLB | |
| SCHEMBL29663621 | 0.81 | RXFP1 (0.55) | RXFP1IDO1LMNATSHRPOLB | |
| SCHEMBL4352600 | 0.80 | KDM4E (0.58) | LMNATSHRPOLBADRA1AADRA1B | |
| SCHEMBL27135684 | 0.80 | CA1 (0.40) | KMT2AMEN1 | |
| SCHEMBL9330701 | 0.80 | KMT2A (0.61) | RXFP1LMNATSHRPOLBKMT2A | |
| SCHEMBL19221305 | 0.79 | RXFP1 (0.39) | RXFP1IDO1LMNATSHRPOLB | |
| SCHEMBL18052443 | 0.79 | NPC1 (0.53) | LMNATSHRPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874686-B2 | Anthranilyl-adenosinemonosulfamate analogs and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-12-29 | — | — | US | disclosed |
| US-10849981-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KemPham, Inc. (US) | 2020-12-01 | — | — | US | disclosed |
| US-10654863-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-10577376-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| US-20200038383-A1 | IMMEDIATE-RELEASE ABUSE DETERRENT COMPOSITIONS OR MEDICAMENTS FOR TREATING PAIN, ADD, ADHD AND OTHER SYNDROMES OR DISORDERS | ALTER DOMUS (US) LLC | 2020-02-06 | — | — | US | disclosed |
| EP-3560336-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | Kempharm, Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-2448407-B1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | KEMPHARM INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-10351573-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | KEMPHARM, INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190160175-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | ALTER DOMUS (US) LLC | 2019-05-30 | — | — | US | disclosed |
| US-20190038656-A1 | ANTHRANILYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | Memorial Slooan-Kettering Cancer Center (US) | 2019-02-07 | — | — | US | disclosed |
| US-8927716-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-8828978-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8759368-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KemPharma, Inc. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8748413-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130259909-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | KEMPHARM, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130252994-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | KEMPHARM, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130245265-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | ALTER DOMUS (US) LLC | 2013-09-19 | — | — | US | disclosed |
| US-8461137-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120142719-A1 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | ALTER DOMUS (US) LLC | 2012-06-07 | — | — | US | disclosed |
| US-20110002990-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130259909-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1383/4885IDO1 988/4885LMNA 1918/4885 |
| US-10874686-B2 | Anthranilyl-adenosinemonosulfamate analogs and uses thereof | ATIC, SLC35B2, ADORA1 | RXFP1 3073/4885IDO1 714/4885LMNA 3488/4885 |
| US-10351573-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1395/4885IDO1 998/4885LMNA 1904/4885 |
| US-10654863-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | RXFP1 2125/4885IDO1 1439/4885LMNA 3436/4885 |
| US-20190160175-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP3A43, CYP2B6, CYP2D6 | RXFP1 2125/4885IDO1 1439/4885LMNA 3436/4885 |
| US-20190038656-A1 | ANTHRANILYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | ATIC, SLC35B2, ADORA1 | RXFP1 3073/4885IDO1 714/4885LMNA 3488/4885 |
| US-20200038383-A1 | IMMEDIATE-RELEASE ABUSE DETERRENT COMPOSITIONS OR MEDICAMENTS FOR TREATING PAIN, ADD, ADHD AND OTHER SYNDROMES OR DISORDERS | OPRK1, OPRL1, OPRD1 | RXFP1 1199/4885IDO1 2341/4885LMNA 3814/4885 |
| US-10577376-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | RXFP1 2125/4885IDO1 1439/4885LMNA 3436/4885 |
| US-20130252994-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1383/4885IDO1 988/4885LMNA 1918/4885 |
| US-20110002990-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1383/4885IDO1 988/4885LMNA 1918/4885 |
| US-20120142719-A1 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1383/4885IDO1 988/4885LMNA 1918/4885 |
| US-10849981-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | CYP3A43, CYP2B6, CYP2D6 | RXFP1 2125/4885IDO1 1439/4885LMNA 3436/4885 |
| US-20130245265-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof | CYP2B6, CYP3A43, CYP2D6 | RXFP1 1383/4885IDO1 988/4885LMNA 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.