Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 18/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29946174 | 1.00 | CASP1 (0.56) | CASP1CTSK | |
| SCHEMBL9925821 | 0.91 | CTSK (0.52) | CASP1CTSK | |
| SCHEMBL29397437 | 0.91 | REN (0.55) | CASP1CTSK | |
| SCHEMBL15485852 | 0.89 | CTSK (0.52) | CASP1CTSK | |
| SCHEMBL29825423 | 0.89 | CASP3 (0.60) | CASP1CTSK | |
| SCHEMBL29453232 | 0.88 | MME (0.58) | CASP1CTSK | |
| SCHEMBL19067195 | 0.87 | CASP1 (0.57) | CASP1CTSK | |
| SCHEMBL7155003 | 0.87 | MME (0.59) | CASP1CTSK | |
| SCHEMBL4430771 | 0.87 | MME (0.59) | CASP1CTSK | |
| SCHEMBL14433707 | 0.87 | MME (0.59) | CASP1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139014-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY AND VASCULAR PERMEABILITY | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-09-18 | — | — | WO | claimed |
| US-20140056964-A1 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-02-27 | — | — | US | claimed |
| EP-2648735-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | The University Of British Columbia (CA) | 2013-10-16 | — | — | EP | claimed |
| WO-2012076985-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-06-14 | — | — | WO | claimed |
| EP-3401406-B1 | STABILISATION AND ISOLATION OF EXTRACELLULAR NUCLEIC ACIDS | PREANALYTIX GMBH (CH) | 2023-11-29 | — | — | EP | disclosed |
| WO-2014139014-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY AND VASCULAR PERMEABILITY | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-09-18 | — | — | WO | disclosed |
| US-20140056964-A1 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-02-27 | — | — | US | disclosed |
| US-20140056964-A1 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-02-27 | — | — | US | disclosed |
| EP-2648735-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | The University Of British Columbia (CA) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076985-A2 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140056964-A1 | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING WOUND HEALING | GZMB, PRF1, SERPINB1 | CASP1 391/4885CTSK 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.