Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11321331 | 1.00 | LMNA (0.37) | LMNAALOX15BLMPMP22GAA | |
| SCHEMBL9862392 | 0.78 | APLNR (0.35) | LMNAALOX15BLMPMP22SLC9A1 | |
| SCHEMBL9909013 | 0.78 | APLNR (0.35) | LMNAALOX15BLMPMP22GAA | |
| SCHEMBL9909003 | 0.78 | APLNR (0.35) | LMNAALOX15BLMPMP22SLC9A1 | |
| SCHEMBL9862146 | 0.78 | APLNR (0.35) | LMNAALOX15BLMPMP22SLC9A1 | |
| SCHEMBL9862088 | 0.78 | APLNR (0.35) | LMNAALOX15BLMPMP22SLC9A1 | |
| SCHEMBL11136897 | 0.76 | SLC9A1 (0.30) | SLC9A1 | |
| SCHEMBL11136894 | 0.76 | SLC9A1 (0.30) | SLC9A1 | |
| Hydrochloric Acid SCHEMBL11138045 | 0.76 | APLNR (0.33) | ALOX15SLC9A1TDP1 | |
| SCHEMBL4208486 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198463-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.3.0]-hexane compounds and enantiomeric salts thereof | SCHERING CORPORATION (US) | 2012-06-12 | — | — | US | disclosed |
| US-8158807-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds utilizing bisulfite intermediate | SCHERING CORPORATION (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100256393-A1 | PROCESS FOR THE PREPARATION OF 6,6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE COMPOUNDS AND ENANTIOMERIC SALTS THEREOF | SCHERING CORPORATION (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100145069-A1 | PROCESS FOR THE PREPARATION OF 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS UTILIZING BISULFITE INTERMEDIATE | SCHERING CORPORATION (US) | 2010-06-10 | — | — | US | disclosed |
| US-7728165-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING PLOUGH CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7723531-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof | SCHERING CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090247784-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF | PARK JEONGHAN | 2009-10-01 | — | — | US | disclosed |
| US-20090240063-A1 | Process For The Preparation Of 6,6-Dimethyl-3-Azabicyclo-[3.1.0]-Hexane Compounds ... | MERCK SHARP & DOHME CORP. | 2009-09-24 | — | — | US | disclosed |
| US-7569705-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof | SCHERING CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-20080114179-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof | MERCK SHARP & DOHME CORP. | 2008-05-15 | — | — | US | disclosed |
| US-7309717-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING CORPORATION (US) | 2007-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256393-A1 | PROCESS FOR THE PREPARATION OF 6,6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE COMPOUNDS AND ENANTIOMERIC SALTS THEREOF | TMT1A, HDHD5, DLST | LMNA 3147/4885ALOX15 1483/4885BLM 4146/4885 |
| US-20080114179-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof | AZI2, MED1, ADH1C | LMNA 3018/4885ALOX15 219/4885BLM 3186/4885 |
| US-20090247784-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF | AZI2, MED1, ALKBH5 | LMNA 3068/4885ALOX15 242/4885BLM 3249/4885 |
| US-20100145069-A1 | PROCESS FOR THE PREPARATION OF 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS UTILIZING BISULFITE INTERMEDIATE | DNMT1, TET2, TET3 | LMNA 3135/4885ALOX15 747/4885BLM 1891/4885 |
| US-20090240063-A1 | Process For The Preparation Of 6,6-Dimethyl-3-Azabicyclo-[3.1.0]-Hexane Compounds ... | TMT1A, HDHD5, TET1 | LMNA 3269/4885ALOX15 1477/4885BLM 4109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.