SCHEMBL9912949

SCHEMBL9912949

Cc1cccc(N(c2cc(N(c3cccc(C)c3)c3ccc4ccccc4c3)cc(-n3c4ccc(N(c5cccc(C)c5)c5ccc6ccccc6c5)cc4c4cc(N(c5cccc(C)c5)c5ccc6ccccc6c5)ccc43)c2)c2ccc3ccccc3c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.38
NR1I2 O75469 1/20 0.38
LMNA P02545 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTR2B P41595 1/20 0.38
CYP51A1 Q16850 1/20 0.38
CYP2A6 P11509 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
OPRD1 P41143 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9912921 0.94 LMNA (0.39) TDP1NR1I2LMNACYP1A2CYP3A4
SCHEMBL9912899 0.91 MAPT (0.39) TDP1NR1I2LMNACYP1A2CYP3A4
SCHEMBL9912958 0.91 ACHE (0.32) TDP1MAPTSIGMAR1SMN1; SMN2MEN1
SCHEMBL9912951 0.90 HTT (0.39) TDP1CYP1A2CYP3A4MAPTCYP2C9
SCHEMBL9912991 0.90 MAPT (0.38) TDP1NR1I2LMNACYP1A2CYP3A4
SCHEMBL9912944 0.90 ALDH1A1 (0.34) TDP1LMNACYP1A2CYP3A4MAPT
SCHEMBL9912943 0.88 KDM4E (0.33) TDP1LMNACYP1A2CYP3A4MAPT
SCHEMBL9912926 0.86 HTT (0.39) TDP1NR1I2LMNACYP1A2CYP3A4
SCHEMBL9912953 0.85 MTNR1A (0.42) LMNACYP1A2MAPTCYP2A6L3MBTL1
SCHEMBL9912948 0.85 SIGMAR1 (0.36) TDP1NR1I2LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8198801-B2 Materials for injecting or transporting holes and organic electroluminescence devices using the same LG CHEM, LTD. (KR) 2012-06-12 US disclosed
US-8198801-B2 Materials for injecting or transporting holes and organic electroluminescence devices using the same LG CHEM, LTD. (KR) 2012-06-12 US disclosed