Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25446073 | 0.82 | KDM4E (0.31) | KDM4ETHRB | |
| SCHEMBL25291731 | 0.79 | MCL1 (0.30) | — | |
| SCHEMBL8667674 | 0.77 | ALDH1A1 (0.40) | PKMKDM4E | |
| SCHEMBL25932264 | 0.72 | L3MBTL1 (0.35) | PKMKDM4ETHRBHTT | |
| SCHEMBL7214346 | 0.71 | PKM (0.33) | PKMKDM4ETHRBHTT | |
| SCHEMBL5891307 | 0.68 | PKM (0.50) | PKMKDM4ETHRBHTT | |
| SCHEMBL3665720 | 0.67 | PKM (0.45) | PKMKDM4ETHRBHTT | |
| SCHEMBL13544391 | 0.66 | NAALAD2 (0.47) | PKMKDM4ETHRBHTT | |
| SCHEMBL5607969 | 0.66 | NAALAD2 (0.47) | PKMKDM4ETHRBHTT | |
| SCHEMBL17439190 | 0.66 | PKM (0.35) | PKMKDM4ETHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933065-B2 | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140342989-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-11-20 | — | — | US | disclosed |
| US-8829033-B2 | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2014-09-09 | — | — | US | disclosed |
| US-20120232015-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-09-13 | — | — | US | disclosed |
| US-20110021482-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE | 2011-01-27 | — | — | US | disclosed |
| US-5986136-A | Photolabeling reagent | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-11-16 | — | — | US | disclosed |
| US-5382485-A | Process for storing information | CIBA-GEIGY CORPORATION (US) | 1995-01-17 | — | — | US | disclosed |
| US-3985715-A | Oxazolidone derivatives of chloromethylated polymers and methods of making the same | OWENS-ILLINOIS, INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3970603-A | Amino acid derivatives of chloromethylated polymers and methods of making the same | OWENS-ILLINOIS, INC. (US) | 1976-07-20 | — | — | US | disclosed |
| US-3969284-A | Amino acid derivatives of chloromethylated polymers and methods of making the same | OWENS-ILLINOIS, INC. (US) | 1976-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021482-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | NAAA, AADAC, GBA1 | PKM 1118/4885KDM4E 3304/4885THRB 2680/4885 |
| US-20140342989-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | NAAA, AADAC, APEH | PKM 1066/4885KDM4E 3119/4885THRB 2451/4885 |
| US-20120232015-A1 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents | NAAA, AADAC, APEH | PKM 1069/4885KDM4E 3105/4885THRB 2503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.