Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9933768 | 0.82 | IDH1 (0.45) | S100A4HTTMAPTKMT2ARECQL | |
| SCHEMBL7950879 | 0.82 | ALDH1A1 (0.42) | S100A4HTTMAPTKMT2ARECQL | |
| SCHEMBL14348206 | 0.82 | DHPS (0.54) | HTTMAPTKMT2ARECQLMCL1 | |
| SCHEMBL31598720 | 0.80 | S100A4 (0.46) | S100A4HTTMAPTKMT2ARECQL | |
| SCHEMBL5906644 | 0.80 | S100A4 (0.46) | S100A4HTTMAPTKMT2ARECQL | |
| SCHEMBL16269233 | 0.80 | ACHE (0.38) | HTTMAPTKMT2ARECQLMCL1 | |
| SCHEMBL30908473 | 0.79 | IDH1 (0.48) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL19582373 | 0.78 | CYP1A2 (0.43) | S100A4HTTMAPTKMT2ARECQL | |
| SCHEMBL3594499 | 0.77 | ACE (0.40) | HTTMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL30450709 | 0.77 | KMT2A (0.47) | S100A4HTTMAPTKMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438044-B1 | COMPOUNDS | JAPAN TOBACCO INC (JP) | 2019-01-23 | — | — | EP | disclosed |
| US-8399481-B2 | Compounds | XENTION LTD (GB) | 2013-03-19 | — | — | US | disclosed |
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | disclosed |
| EP-2438044-A1 | COMPOUNDS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| US-20110136859-A1 | Compounds | XENTION LTD. (GB) | 2011-06-09 | — | — | US | disclosed |
| WO-2010139953-A1 | COMPOUNDS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136859-A1 | Compounds | CYP2C8, CYP3A7, CYP2A7 | S100A4 4591/4885HTT 3400/4885MAPT 4581/4885 |
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | P2RX7, P2RX3, P2RX1 | S100A4 1340/4885HTT 2112/4885MAPT 3117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.