SCHEMBL9945871

SCHEMBL9945871

Cc1c(F)c(F)c(C(C)C)c(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 7/20 0.35
TAS1R1 Q7RTX1 7/20 0.35
TAS1R2 Q8TE23 7/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12859001 0.94 TAS1R3 (0.33) TAS1R3TAS1R1TAS1R2
SCHEMBL18745493 0.92 TAS1R3 (0.32) TAS1R3TAS1R1TAS1R2
SCHEMBL12912877 0.91 TAS1R3 (0.34) TAS1R3TAS1R1TAS1R2
SCHEMBL24250416 0.88 TAS1R3 (0.33) TAS1R3TAS1R1TAS1R2
SCHEMBL12946115 0.88 TAS1R3 (0.31) TAS1R3TAS1R1TAS1R2
SCHEMBL13105370 0.87 TAS1R3 (0.31) TAS1R3TAS1R1TAS1R2
SCHEMBL23105014 0.87 TAS1R3 (0.31) TAS1R3TAS1R1TAS1R2
SCHEMBL12180002 0.87
SCHEMBL18745544 0.85
SCHEMBL24282821 0.85 TAS1R3 (0.32) TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4306538-A2 PEPTIDE OLIGONUCLEOTIDE CONJUGATES Sarepta Therapeutics, Inc. (US) 2024-01-17 EP disclosed
US-20230337677-A1 ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2023-10-26 US disclosed
US-20230293701-A1 LIGAND COMPOUNDS, CONJUGATES, AND APPLICATIONS THEREOF ARGORNA PHARMACEUTICALS CO., LTD. (CN) 2023-09-21 US disclosed
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 US disclosed
US-20230265055-A1 STAT INIHIBITORY COMPOUNDS AND COMPOSITIONS OXFORD FINANCE LLC 2023-08-24 US disclosed
WO-2023118576-A1 DHODH INHIBITORS CONTAINING A CARBOXYLIC ACID BIOISOSTERE IMMUNIC AG (DE) 2023-06-29 WO disclosed
US-20230174506-A1 (DI)AMINATION OF ACTIVATED ALLENE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR SYNTHESIS OF THE SAME PURDUE RESEARCH FOUNDATION 2023-06-08 US disclosed
US-20230150946-A1 HETEROCYCLE CONTAINING STAT INHIBITORS AND COMPOSITIONS OXFORD FINANCE LLC 2023-05-18 US disclosed
US-20230137943-A1 PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS THE UNIVERSITY OF CHICAGO 2023-05-04 US disclosed
US-11612604-B2 Methods of treating cancer with PLK4 inhibitors LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) 2023-03-28 US disclosed
US-20110045100-A1 Antimalarial Quinolines and Methods of Use Thereof GEORGETOWN UNIVERSITY (US) 2011-02-24 US disclosed
US-20100317643-A1 JANUS KINASE INHIBITOR COMPOUNDS AND METHODS GENENTECH, INC. (US) 2010-12-16 US disclosed
US-20100284953-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. (US) 2010-11-11 US disclosed
US-20100284939-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. (US) 2010-11-11 US disclosed
US-7785575-B2 controlling frizz in scalp hair by applying a mixture of a nonpolymeric fluorinated ester such as hexafluoroisopropyl 2-fluoroacrylate, water, emulsifiers and flow control agents LIVING PROOF, INC. (US) 2010-08-31 US disclosed
US-7763240-B2 Hair care compositions and methods of treating hair using same LIVING PROOF, INC. (US) 2010-07-27 US disclosed
US-20100035070-A1 FUSER MEMBER COATING HAVING POLYSILSESQUIOXANE OUTER LAYER XEROX CORPORATION (US) 2010-02-11 US disclosed
US-20090226382-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. (US) 2009-09-10 US disclosed
US-20090191141-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. (US) 2009-07-30 US disclosed
US-20090104136-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. 2009-04-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150946-A1 HETEROCYCLE CONTAINING STAT INHIBITORS AND COMPOSITIONS STAT5A, STAT5B, STAT3 TAS1R3 3958/4885TAS1R1 3882/4885TAS1R2 3968/4885
US-20100284939-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 TAS1R3 998/4885TAS1R1 1349/4885TAS1R2 1592/4885
US-20090226382-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 TAS1R3 998/4885TAS1R1 1349/4885TAS1R2 1592/4885
US-20230174506-A1 (DI)AMINATION OF ACTIVATED ALLENE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR SYNTHESIS OF THE SAME NAAA, PAM, AANAT TAS1R3 4567/4885TAS1R1 4554/4885TAS1R2 4543/4885
US-11612604-B2 Methods of treating cancer with PLK4 inhibitors PLK4, PLK2, PLK3 TAS1R3 4831/4885TAS1R1 4853/4885TAS1R2 4849/4885
US-20100317643-A1 JANUS KINASE INHIBITOR COMPOUNDS AND METHODS JAK2, JAK1, JAK3 TAS1R3 1766/4885TAS1R1 1466/4885TAS1R2 1886/4885
US-20100284953-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 TAS1R3 998/4885TAS1R1 1349/4885TAS1R2 1592/4885
US-20110045100-A1 Antimalarial Quinolines and Methods of Use Thereof NQO2, QTRT1, QTRT2 TAS1R3 4519/4885TAS1R1 4721/4885TAS1R2 4636/4885
US-20090104136-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 TAS1R3 998/4885TAS1R1 1349/4885TAS1R2 1592/4885
US-20230137943-A1 PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS PPIA, S100A4, S100A6 TAS1R3 4658/4885TAS1R1 4785/4885TAS1R2 4783/4885
US-20090191141-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 TAS1R3 998/4885TAS1R1 1349/4885TAS1R2 1592/4885
US-20230337677-A1 ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF DDT, ACHE, AHR TAS1R3 1182/4885TAS1R1 2105/4885TAS1R2 1899/4885
US-20230293701-A1 LIGAND COMPOUNDS, CONJUGATES, AND APPLICATIONS THEREOF ASGR1, HAVCR2, SLC10A1 TAS1R3 2609/4885TAS1R1 2512/4885TAS1R2 2407/4885
US-20230265055-A1 STAT INIHIBITORY COMPOUNDS AND COMPOSITIONS STAT5B, STAT5A, STAT3 TAS1R3 4187/4885TAS1R1 4055/4885TAS1R2 4043/4885
US-11760775-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 TAS1R3 4800/4885TAS1R1 4781/4885TAS1R2 4803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.