Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPD | P32754 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953024 | 0.88 | CA12 (0.52) | MEN1KMT2AAPPHPDMAPT | |
| SCHEMBL10289024 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2USP2TP53MEN1GAA | |
| SCHEMBL9954100 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2USP2TP53MEN1GAA | |
| SCHEMBL9953324 | 0.85 | HCAR1 (0.50) | PI4KAPIK3CGKDM4E | |
| SCHEMBL9955586 | 0.83 | HPD (0.44) | SMN1; SMN2MEN1KMT2API4KAPIK3CG | |
| SCHEMBL9953665 | 0.83 | TGM2 (0.45) | PI4KAPIK3CGHPD | |
| SCHEMBL9955061 | 0.80 | PIK3CG (0.48) | SMN1; SMN2MEN1GAAKMT2API4KA | |
| SCHEMBL9954546 | 0.80 | PI4KA (0.44) | PI4KAPIK3CG | |
| SCHEMBL9953800 | 0.79 | POLB (0.41) | PI4KAPIK3CGPOLB | |
| SCHEMBL9954341 | 0.79 | L3MBTL1 (0.51) | TP53MEN1KMT2AHPDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |