Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18975330 | 0.88 | CHRNB2 (0.35) | ROCK2HTR1B | |
| SCHEMBL9964990 | 0.84 | KDM4E (0.36) | KDM4EROCK2HTR7NOS3NOS1 | |
| SCHEMBL9964955 | 0.83 | IDO1 (0.33) | — | |
| SCHEMBL9965021 | 0.81 | MEN1 (0.41) | KDM4EGAA | |
| SCHEMBL9964978 | 0.76 | CYP19A1 (0.46) | KDM4EGAA | |
| SCHEMBL9936519 | 0.74 | ROCK2 (0.33) | KDM4EROCK2HTR7GAA | |
| SCHEMBL9964966 | 0.71 | KDM4E (0.43) | KDM4EROCK2HTR7NOS3NOS1 | |
| SCHEMBL9964956 | 0.70 | RAB9A (0.36) | — | |
| SCHEMBL17364542 | 0.69 | KDM4E (0.39) | KDM4EGAA | |
| SCHEMBL18975532 | 0.69 | KDM4E (0.43) | KDM4EROCK2HTR7NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | claimed |
| US-11013675-B2 | Dye composition comprising a para-phenylenediamine oxidation base and a particular coupler | L'OREAL (FR) | 2021-05-25 | — | — | US | disclosed |
| US-20200108001-A1 | DYE COMPOSITION COMPRISING A PARA-PHENYLENEDIAMINE OXIDATION BASE AND A PARTICULAR COUPLER | L'OREAL (FR) | 2020-04-09 | — | — | US | disclosed |
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | disclosed |
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016097022-A1 | DYE COMPOSITION COMPRISING A PARA-PHENYLENEDIAMINE OXIDATION BASE AND A PARTICULAR COUPLER | L'OREAL (FR) | 2016-06-23 | — | — | WO | disclosed |
| US-9220671-B2 | Dye composition comprising at least four dye precursors including at least one oxidation base and at least one coupler | L'OREAL (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9220671-B2 | Dye composition comprising at least four dye precursors including at least one oxidation base and at least one coupler | L'OREAL (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9125834-B2 | Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler | L'OREAL (FR) | 2015-09-08 | — | — | US | disclosed |
| US-9125834-B2 | Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler | L'OREAL (FR) | 2015-09-08 | — | — | US | disclosed |
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2014-09-18 | — | — | US | disclosed |
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2014-09-18 | — | — | US | disclosed |
| US-8623100-B2 | 4-aminoindole derivatives and use thereof for the oxidation dyeing of keratin fibres | L'OREAL (FR) | 2014-01-07 | — | — | US | disclosed |
| US-8623100-B2 | 4-aminoindole derivatives and use thereof for the oxidation dyeing of keratin fibres | L'OREAL (FR) | 2014-01-07 | — | — | US | disclosed |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2013-10-10 | — | — | US | disclosed |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2013-10-10 | — | — | US | disclosed |
| WO-2012080289-A2 | DYE COMPOSITION COMPRISING AT LEAST FOUR DYE PRECURSORS INCLUDING AT LEAST ONE OXIDATION BASE AND AT LEAST ONE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080321-A2 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080288-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080285-A2 | DYE COMPOSITION COMPRISING A SECONDARY PARA-PHENYLENEDIAMINE OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | KRT18, NDUFS5, NDUFS3 | KDM4E 528/4885ROCK2 4647/4885HTR7 770/4885 |
| US-20200108001-A1 | DYE COMPOSITION COMPRISING A PARA-PHENYLENEDIAMINE OXIDATION BASE AND A PARTICULAR COUPLER | KRT18, DSG1, PYCR1 | KDM4E 2174/4885ROCK2 4674/4885HTR7 2226/4885 |
| US-11013675-B2 | Dye composition comprising a para-phenylenediamine oxidation base and a particular coupler | KRT18, DSG1, PYCR1 | KDM4E 2174/4885ROCK2 4674/4885HTR7 2226/4885 |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | KRT18, AADAT, KMO | KDM4E 423/4885ROCK2 4086/4885HTR7 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.