Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10301504 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AKDM4EKCNH3 | |
| SCHEMBL13241915 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AKDM4EKCNH3 | |
| SCHEMBL6549892 | 0.86 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL6550392 | 0.86 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL4373923 | 0.86 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL2045447 | 0.81 | RIPK1 (0.32) | — | |
| SCHEMBL13602495 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AKDM4EKCNH3 | |
| SCHEMBL10041431 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AKDM4EKCNH3 | |
| SCHEMBL10041430 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AKDM4EKCNH3 | |
| SCHEMBL28044234 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993547-B2 | 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-03-31 | — | — | US | disclosed |
| US-8785422-B2 | A-ring modified 19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-07-22 | — | — | US | disclosed |
| US-8729054-B2 | 3-desoxy-2-methylene-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-05-20 | — | — | US | disclosed |
| US-20140045860-A1 | SMALL MOLECULE INHIBITORS FOR TREATING PARASITIC INFECTIONS | NEW YORK UNIVERSITY (US) | 2014-02-13 | — | — | US | disclosed |
| US-8518917-B2 | 2-methylene-19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-08-27 | — | — | US | disclosed |
| US-8455467-B2 | 2-methylene-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-06-04 | — | — | US | disclosed |
| US-20130102567-A1 | 3-Desoxy-2-Methylene-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102573-A1 | 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102574-A1 | 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-25 | — | — | US | disclosed |
| US-8410080-B1 | 2-methylene-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410080-B1 | 2-methylene-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120322775-A1 | 3-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120157418-A1 | 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157418-A1 | 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| US-20080249068-A1 | Method of Extending the Dose Range of Vitamin D Compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-10-09 | — | — | US | disclosed |
| US-7259143-B2 | Method of extending the dose range of vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045860-A1 | SMALL MOLECULE INHIBITORS FOR TREATING PARASITIC INFECTIONS | CYP51A1, GDI1, GDI2 | ALDH1A1 636/4885MEN1 1963/4885KMT2A 2160/4885 |
| US-20080249068-A1 | Method of Extending the Dose Range of Vitamin D Compounds | VDR, CASK, CYP24A1 | ALDH1A1 4114/4885MEN1 135/4885KMT2A 3995/4885 |
| US-20130102567-A1 | 3-Desoxy-2-Methylene-Vitamin D Analogs and Their Uses | VDR, CYP24A1, CYP2R1 | ALDH1A1 479/4885MEN1 549/4885KMT2A 3355/4885 |
| US-20130102574-A1 | 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES | CYP24A1, VDR, CYP27B1 | ALDH1A1 142/4885MEN1 812/4885KMT2A 2125/4885 |
| US-20120157418-A1 | 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | CYP24A1, CYP2R1, CYP27B1 | ALDH1A1 185/4885MEN1 1446/4885KMT2A 3021/4885 |
| US-20130102573-A1 | 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES | VDR, CYP24A1, CYP2R1 | ALDH1A1 291/4885MEN1 899/4885KMT2A 1840/4885 |
| US-20120322775-A1 | 3-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | VDR, CYP24A1, CYP2R1 | ALDH1A1 458/4885MEN1 1006/4885KMT2A 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.