SCHEMBL9972127

SCHEMBL9972127

Cc1cc(C=CC=Cc2ccccc2)ccc1N(C=C(c1ccccc1)c1ccccc1)c1ccc(C=CC=Cc2ccccc2)c2ccccc12

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.33
PTGS1 P23219 2/20 0.33
PTGS2 P35354 2/20 0.33
ALOX5 P09917 1/20 0.33
BACE1 P56817 1/20 0.33
MAPT P10636 3/20 0.32
RAB9A P51151 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
LMNA P02545 2/20 0.32
HTT P42858 1/20 0.32
IP6K1 Q92551 1/20 0.32
MAOB P27338 1/20 0.31
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9972125 0.93 TTR (0.38) TTRPTGS1PTGS2ALOX5BACE1
SCHEMBL9972133 0.91 TTR (0.35) TTRPTGS1PTGS2ALOX5MAPT
SCHEMBL14081210 0.89 MAOB (0.39) ALOX5MAPTRAB9AKDM4ELMNA
SCHEMBL12422879 0.86 RELA (0.36) PTGS1PTGS2ALOX5MAPTRAB9A
SCHEMBL9972131 0.85 MAOB (0.35) KDM4ELMNAMAOB
SCHEMBL13990770 0.83 ALDH1A1 (0.35) PTGS2ALOX5MAPTKDM4ELMNA
SCHEMBL12549940 0.83 ALDH1A1 (0.35) PTGS2ALOX5MAPTKDM4ELMNA
SCHEMBL9972126 0.83 PTGS2 (0.35) PTGS2
SCHEMBL13990768 0.83 MAOB (0.33) MAPTL3MBTL1LMNAHTTMAOB
SCHEMBL18157322 0.83 TRPM8 (0.32) MAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120156599-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND IMAGE FORMING APPARATUS INCLUDING THE SAME SHARP KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed
US-20120156599-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND IMAGE FORMING APPARATUS INCLUDING THE SAME SHARP KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed