Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17308142 | 0.83 | MAPT (0.40) | MAPTCYP2C9MEN1KMT2AHTT | |
| SCHEMBL11016783 | 0.80 | ALDH1A1 (0.36) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL13434042 | 0.78 | MAPT (0.38) | MAPTCYP2C9KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL21851252 | 0.78 | LMNA (0.34) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL24333915 | 0.77 | ELANE (0.41) | KMT2AALDH1A1ELANESMN1; SMN2 | |
| SCHEMBL25067973 | 0.75 | — | — | |
| SCHEMBL17308140 | 0.70 | CYP2C19 (0.38) | MEN1KMT2AHTTCYP2C19ALDH1A1 | |
| SCHEMBL23567967 | 0.70 | EGFR (0.37) | MAPTMEN1KMT2AHTTCYP2C19 | |
| SCHEMBL21884000 | 0.69 | MEN1 (0.44) | MAPTCYP2C9MEN1KMT2AHTT | |
| SCHEMBL26197278 | 0.69 | EGFR (0.36) | MAPTCYP2C9KMT2ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751076-B1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | MEDIMMUNE LTD (GB) | 2018-04-25 | — | — | EP | disclosed |
| US-9102704-B2 | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines | SPIROGEN SARL (CH) | 2015-08-11 | — | — | US | disclosed |
| US-20140275522-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | SPIROGEN SÁRL (CH) | 2014-09-18 | — | — | US | disclosed |
| US-8829184-B2 | Intermediates useful for the synthesis of pyrrolobenzodiazepines | SPIROGEN SARL (CH) | 2014-09-09 | — | — | US | disclosed |
| US-8779191-B2 | Methods and compositions for preparing lisdexamfetamine and salts thereof | CAMBREX CHARLES CITY, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130035484-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | SPIROGEN DEVELOPMENTS SÀRL (CH) | 2013-02-07 | — | — | US | disclosed |
| US-20120190880-A1 | METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF | BLUE OWL CAPITAL CORPORATION, AS NEW AGENT | 2012-07-26 | — | — | US | disclosed |
| US-20120157706-A1 | Methods and Compositions for Preparing Lisdexamfetamine and Salts Thereof | AVISTA PHARMA SOLUTIONS, INC. | 2012-06-21 | — | — | US | disclosed |
| US-20100056497-A1 | AMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2010-03-04 | — | — | US | disclosed |
| US-20100056497-A1 | AMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190880-A1 | METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF | PNMT, COMT, DDT | MAPT 350/4885CYP2C9 136/4885MEN1 1108/4885 |
| US-20120157706-A1 | Methods and Compositions for Preparing Lisdexamfetamine and Salts Thereof | SLC6A3, COMT, LPXN | MAPT 60/4885CYP2C9 223/4885MEN1 2241/4885 |
| US-20140275522-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | ORC3, OXER1, SCO2 | MAPT 4429/4885CYP2C9 233/4885MEN1 2359/4885 |
| US-20100056497-A1 | AMIDE DERIVATIVE | REN, AGTR1, AGTR2 | MAPT 3478/4885CYP2C9 392/4885MEN1 825/4885 |
| US-20130035484-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | CYP11B2, CYP1B1, CYP11B1 | MAPT 2289/4885CYP2C9 61/4885MEN1 1060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.