LOXL4

Lysyl oxidase homolog 4 · Q96JB6 · LOXL4 on Sugi Atlas →

2,229 patent compounds predicted against LOXL4, 1,590 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Thiram (SCHEMBL21144)	1.00	2/20
Disulfiram (SCHEMBL27213)	1.00	2/20
Thiram (SCHEMBL1216571)	1.00	2/20
Disulfiram (SCHEMBL4654748)	1.00	2/20
Hydrochloric Acid (SCHEMBL19211738)	1.00	2/20
Hydrochloric Acid (SCHEMBL19211740)	1.00	2/20
Disulfiram (SCHEMBL5364281)	0.94	2/20
Disulfiram (SCHEMBL5961375)	0.94	2/20
Disulfiram (SCHEMBL10886601)	0.94	2/20
Disulfiram (SCHEMBL11155542)	0.94	2/20
Thiram (SCHEMBL80195)	0.93	2/20
Thiram (SCHEMBL223860)	0.93	2/20
Thiram (SCHEMBL234787)	0.93	2/20
Thiram (SCHEMBL2773352)	0.93	2/20
Thiram (SCHEMBL2773357)	0.93	2/20
Thiram (SCHEMBL3741643)	0.93	2/20
Thiram (SCHEMBL3919769)	0.93	2/20
Thiram (SCHEMBL10881913)	0.93	2/20
Thiram (SCHEMBL10882319)	0.93	2/20
Thiram (SCHEMBL10883678)	0.93	2/20

Clinical trials — most relevant to LOXL4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Veliflapon (DG-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina	PHASE3	SUSPENDED
Aspirin for Uncontrolled Asthma	PHASE3	COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Predicting the Response to Montelukast by Genetic Variation in Asthmatics	PHASE3	COMPLETED
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
GSK2190915 Neutrophilic Asthma Study	PHASE2	COMPLETED
Endometriosis and Microvascular Dysfunction: Role of Inflammation	EARLY_PHASE1	RECRUITING
A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma	nan	COMPLETED
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing	nan	UNKNOWN
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
The Effectiveness of Montelukast on Atopic Dermatitis in Koreans	nan	COMPLETED
Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome	nan	UNKNOWN
Developing a Management Approach for Patients With Late-Onset Pompe Disease	nan	ACTIVE_NOT_RECRUITING
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia	nan	RECRUITING
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Gene Expression in Chronic Venous Leg Ulcers	nan	UNKNOWN
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis	nan	UNKNOWN
A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype	nan	COMPLETED
for Adipose Tissue DIabetes VAriants (fATDIVA)	nan	COMPLETED
Construction of a Reference Corridor to Assess the Value of Combining Innovative Morphological and Functional Analysis Techniques in Pediatric Patient Care Based on Different Pathological Models	nan	NOT_YET_RECRUITING
Gene First Approach to Connective Tissue Disease	nan	COMPLETED
The Genetics of Environmental Asthma	nan	COMPLETED
Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.	nan	NOT_YET_RECRUITING
Natural History and Outcomes in X-Linked Hypohidrotic Ectodermal Dysplasia	nan	COMPLETED
Imaging Genetics of Laryngeal Dystonia	nan	RECRUITING
Inflammatory Genomics in Human Carotid Artery Disease	nan	COMPLETED
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LOXL4 binder may also engage these)

Protein	Name	Similarity
LOXL3	Lysyl oxidase homolog 3	1.000	landscape →
Q924C6	—	1.000	Q924C6 →
Q8MJ24	—	1.000	Q8MJ24 →
Q9Z175	—	1.000	Q9Z175 →
B4F6N6	—	0.996	B4F6N6 →
Q5RFQ6	—	0.992	Q5RFQ6 →
LOXL2	Lysyl oxidase homolog 2	0.991	landscape →
Q5G265	—	0.990	Q5G265 →
F1RD85	—	0.989	F1RD85 →
B8A4W9	—	0.989	B8A4W9 →
E1C3U7	—	0.989	E1C3U7 →
A6H737	—	0.989	A6H737 →
Q08B63	—	0.988	Q08B63 →
P58022	—	0.988	P58022 →
Q5G270	—	0.987	Q5G270 →
Q5G266	—	0.987	Q5G266 →
Q5G268	—	0.987	Q5G268 →
O08762	—	0.986	O08762 →
Q3U435	—	0.986	Q3U435 →
Q5G269	—	0.986	Q5G269 →
A1L1V4	—	0.986	A1L1V4 →
PRSS12	Neurotrypsin	0.986	landscape →
Q9R097	—	0.985	Q9R097 →
B5DF27	—	0.985	B5DF27 →
Q9DBX3	—	0.985	Q9DBX3 →
Q08E66	—	0.985	Q08E66 →
Q96SM3	—	0.985	Q96SM3 →
Q5G267	—	0.984	Q5G267 →
Q5G271	—	0.984	Q5G271 →
D3ZTE0	—	0.984	D3ZTE0 →