Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.62 |
| ▸ | TUBB | P07437 | 2/20 | 0.62 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.62 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.62 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.62 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.62 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.62 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.62 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.62 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.62 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.62 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.62 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.62 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.62 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10136222 | 0.94 | APP (0.65) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL786868 | 0.92 | TUBB1 (0.52) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17145738 | 0.92 | MMP2 (0.54) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13079742 | 0.91 | TUBB1 (0.65) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12810214 | 0.89 | TUBB1 (0.52) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12810366 | 0.89 | TUBB1 (0.51) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13223566 | 0.87 | TUBB1 (0.49) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL91388 | 0.86 | TUBB1 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12774233 | 0.86 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17145742 | 0.86 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951049-B2 | Pyrazole linked benzimidazole conjugates and a process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | disclosed |
| US-20160304525-A1 | Cyclopenta[d]pyrimidines And Substituted Cyclopenta[d]pyrimidines As Antitubulin and Microtubule Targeting Agents, Monocyclic Pyrimidines As Tubulin Inhibitors, And Pyrrolopyrimidines As Targeted Antifolates And Tubulin and Multiple Receptor Tyrosine Kinase Inhibition And Antitumor Agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-10-20 | — | — | US | disclosed |
| US-RE45907-E1 | Functionalized stilbene derivatives as improved vascular targeting agents | OXIGENE, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150329527-A1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-11-19 | — | — | US | disclosed |
| US-RE45720-E1 | Functionalized stilbene derivatives as improved vascular targeting agents | OXIGENE, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-8980933-B2 | Combretastatin analogs for use in the treatment of cancer | UNIVERSITAT BAYREUTH (DE) | 2015-03-17 | — | — | US | disclosed |
| US-20150065727-A1 | THE NEW DERIVATIVES OF (Z)-1,2-DIPHENYLETHENE | UNIWERSYTET MEDYCZNY IM. KAROLA MARCINKOWSKIEGO (PL) | 2015-03-05 | — | — | US | disclosed |
| US-8883809-B2 | Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-11 | — | — | US | disclosed |
| US-20130137740-A1 | COMBRETASTATIN ANALOGS FOR USE IN THE TREATMENT OF CANCER | MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG | 2013-05-30 | — | — | US | disclosed |
| US-20120309734-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2012-12-06 | — | — | US | disclosed |
| US-20120046492-A1 | Ethoxy Diphenyl Ethane Derivatives, Preparation Processes and Uses Thereof | Zhejiang Wild Wind Pharmaceutical Co., Ltd. (CN) | 2012-02-23 | — | — | US | disclosed |
| US-20110054035-A1 | Combination Comprising Combretastatin and Anticancer Agents | AVENTIS PHARMA S.A. (FR) | 2011-03-03 | — | — | US | disclosed |
| US-20110054035-A1 | Combination Comprising Combretastatin and Anticancer Agents | AVENTIS PHARMA S.A. (FR) | 2011-03-03 | — | — | US | disclosed |
| US-7851443-B2 | Combination comprising combretastatin and anticancer agents | AVENTIS PHARMA SA (FR) | 2010-12-14 | — | — | US | disclosed |
| US-7838706-B2 | Preparation and the use of ethoxy combretastatins and their prodrugs | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2010-11-23 | — | — | US | disclosed |
| US-7786098-B2 | Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD. (CN) | 2010-08-31 | — | — | US | disclosed |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2009-07-02 | — | — | US | disclosed |
| US-20090023656-A1 | Combination Comprising Combretastatin and Anticancer Agents | AVENTIS PHARMA S.A. (FR) | 2009-01-22 | — | — | US | disclosed |
| US-20080306027-A1 | Fluoroalkoxycombretastatin Derivatives, Method For Producing the Same and Use Thereof | ZHEJIANG DADE PHARMACEUTICAL GROUP CO., LTD. (CN) | 2008-12-11 | — | — | US | disclosed |
| US-20070149476-A1 | Combination Comprising Combretastatin and Anticancer Agents | AVENTIS PHARMA S.A. (FR) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149476-A1 | Combination Comprising Combretastatin and Anticancer Agents | TOP1, TOP2A, TOP2B | TUBB1 110/4885TUBB4A 112/4885TUBB 106/4885 |
| US-20090023656-A1 | Combination Comprising Combretastatin and Anticancer Agents | TEK, FLT4, FLT1 | TUBB1 47/4885TUBB4A 76/4885TUBB 46/4885 |
| US-20160304525-A1 | Cyclopenta[d]pyrimidines And Substituted Cyclopenta[d]pyrimidines As Antitubulin and Microtubule Targeting Agents, Monocyclic Pyrimidines As Tubulin Inhibitors, And Pyrrolopyrimidines As Targeted Antifolates And Tubulin and Multiple Receptor Tyrosine Kinase Inhibition And Antitumor Agents | FOLR1, TUBB1, TUBA1C | TUBB1 2/4885TUBB4A 27/4885TUBB 5/4885 |
| US-20130137740-A1 | COMBRETASTATIN ANALOGS FOR USE IN THE TREATMENT OF CANCER | ABCC1, ABCB1, HMGCR | TUBB1 182/4885TUBB4A 412/4885TUBB 194/4885 |
| US-20120309734-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | CASP4, CA4, ACSL4 | TUBB1 728/4885TUBB4A 157/4885TUBB 699/4885 |
| US-20080306027-A1 | Fluoroalkoxycombretastatin Derivatives, Method For Producing the Same and Use Thereof | TUBB, TUBB1, TUBB3 | TUBB1 2/4885TUBB4A 7/4885TUBB 1/4885 |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | PHOSPHO1, TUBB3, TYMP | TUBB1 5/4885TUBB4A 10/4885TUBB 4/4885 |
| US-20110054035-A1 | Combination Comprising Combretastatin and Anticancer Agents | TEK, FLT4, FLT1 | TUBB1 47/4885TUBB4A 76/4885TUBB 46/4885 |
| US-20150065727-A1 | THE NEW DERIVATIVES OF (Z)-1,2-DIPHENYLETHENE | TUBB1, TUBA1C, TUBB3 | TUBB1 1/4885TUBB4A 22/4885TUBB 6/4885 |
| US-20150329527-A1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | BRDT, MCL1, MGST3 | TUBB1 515/4885TUBB4A 809/4885TUBB 676/4885 |
| US-20120046492-A1 | Ethoxy Diphenyl Ethane Derivatives, Preparation Processes and Uses Thereof | TUBB1, TUBB, TUBB3 | TUBB1 1/4885TUBB4A 6/4885TUBB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.