SCHEMBL10034716

SCHEMBL10034716

CC(C)(C)CCCOC(=O)C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PRKCA P17252 2/20 0.38
CYP4F2 P78329 2/20 0.37
CYP4A11 Q02928 2/20 0.37
ALDH1A1 P00352 1/20 0.33
PPARA Q07869 3/20 0.32
ATM Q13315 1/20 0.31
ELANE P08246 1/20 0.31
BRD4 O60885 1/20 0.30
NAAA Q02083 1/20 0.30
TTR P02766 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C8 P10632 1/20 0.30
CHRM1 P11229 1/20 0.30
CYP2C9 P11712 1/20 0.30
TSHR P16473 1/20 0.30
ADRA1A P35348 1/20 0.30
PPARG P37231 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11954968 0.93 CYP4F2 (0.40) POLBGAANPSR1PRKCACYP4F2
SCHEMBL26328701 0.91 CYP4F2 (0.43) POLBGAANPSR1PRKCACYP4F2
SCHEMBL1753756 0.86 POLB (0.43) POLBGAANPSR1PRKCACYP4F2
SCHEMBL27819169 0.85 POLB (0.46) POLBGAANPSR1PRKCACYP4F2
SCHEMBL7989588 0.85 POLB (0.46) POLBGAANPSR1PRKCACYP4F2
SCHEMBL29049106 0.83 POLB (0.44) POLBGAANPSR1PRKCACYP4F2
SCHEMBL16017798 0.83 ADRA2A (0.37) POLBGAANPSR1PRKCACYP4F2
SCHEMBL15223097 0.83 POLB (0.34) POLBGAANPSR1PRKCACYP4F2
SCHEMBL16641610 0.83 CYP4F2 (0.32) CYP4F2CYP4A11ALDH1A1
SCHEMBL21448666 0.83 CYP4F2 (0.39) POLBGAANPSR1PRKCACYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180153861-A1 METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2018-06-07 US disclosed
US-20180147289-A9 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2018-05-31 US disclosed
US-20180133316-A9 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2018-05-17 US disclosed
US-20170333567-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2017-11-23 US disclosed
US-20170274090-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2017-09-28 US disclosed
US-9629924-B2 Conjugates of CC-1065 analogs and bifunctional linkers SYNTARGA BV (NL) 2017-04-25 US disclosed
US-20160058873-A1 Cyclodextrin-Based Polymers for Therapeutic Delivery CERULEAN PHARMA INC (US) 2016-03-03 US disclosed
US-20150209440-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. (US) 2015-07-30 US disclosed
US-20140328919-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. (US) 2014-11-06 US disclosed
US-20140328918-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS CERULEAN PHARMA INC. (US) 2014-11-06 US disclosed
US-20120302622-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS CERULEAN PHARMA INC. (US) 2012-11-29 US disclosed
US-20120282306-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2012-11-08 US disclosed
US-20120225129-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS CERULEAN PHARMA INC. (US) 2012-09-06 US disclosed
US-20120213854-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS CERULEAN PHARMA INC. 2012-08-23 US disclosed
US-20120052097-A1 THERAPEUTIC PEPTIDE-POLYMER CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS CERULEAN PHARMA INC. (US) 2012-03-01 US disclosed
US-20120041019-A1 PROTEASE INHIBITORS AMPLYX PHARMACEUTICALS, INC. 2012-02-16 US disclosed
US-20110268658-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2011-11-03 US disclosed
US-20110262490-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2011-10-27 US disclosed
US-20110237686-A1 FORMULATIONS AND METHODS OF USE CERULEAN PHARMA INC (US) 2011-09-29 US disclosed
US-20110189092-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2011-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (19 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170274090-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L POLB 230/4885GAA 971/4885NPSR1 3469/4885
US-20170333567-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L POLB 230/4885GAA 971/4885NPSR1 3469/4885
US-20160058873-A1 Cyclodextrin-Based Polymers for Therapeutic Delivery IAPP, PRCP, DDOST POLB 3741/4885GAA 76/4885NPSR1 673/4885
US-20120052097-A1 THERAPEUTIC PEPTIDE-POLYMER CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS IAPP, PSAP, LNPEP POLB 1780/4885GAA 194/4885NPSR1 312/4885
US-20110268658-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 POLB 231/4885GAA 114/4885NPSR1 915/4885
US-20120302622-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS SYNCRIP, EXOSC5, EXOSC9 POLB 127/4885GAA 869/4885NPSR1 1363/4885
US-20120041019-A1 PROTEASE INHIBITORS SERPINB1, PREP, DNPEP POLB 1065/4885GAA 193/4885NPSR1 3816/4885
US-20180153861-A1 METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS CETP, MTTP, APOB POLB 3082/4885GAA 716/4885NPSR1 2348/4885
US-20180133316-A9 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L POLB 230/4885GAA 971/4885NPSR1 3469/4885
US-20110262490-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 POLB 231/4885GAA 114/4885NPSR1 915/4885
US-20140328918-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS HLA-DRB1, TSG101, IAPP POLB 2610/4885GAA 38/4885NPSR1 1355/4885
US-20150209440-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CD44, DIS3, POLN POLB 79/4885GAA 831/4885NPSR1 1110/4885
US-20120213854-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS HLA-DRB1, TSG101, IAPP POLB 2610/4885GAA 38/4885NPSR1 1355/4885
US-20140328919-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 POLB 231/4885GAA 114/4885NPSR1 915/4885
US-20120282306-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 POLB 231/4885GAA 114/4885NPSR1 915/4885
US-20180147289-A9 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L POLB 230/4885GAA 971/4885NPSR1 3469/4885
US-20110237686-A1 FORMULATIONS AND METHODS OF USE LPXN, LIPA, CHMP4B POLB 3704/4885GAA 494/4885NPSR1 328/4885
US-20110189092-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 POLB 231/4885GAA 114/4885NPSR1 915/4885
US-20120225129-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS SYNCRIP, EXOSC5, EXOSC9 POLB 127/4885GAA 869/4885NPSR1 1363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.