SCHEMBL10074884

SCHEMBL10074884

COC(C)(C)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13347914 0.83 MGLL (0.30) MGLL
SCHEMBL12057095 0.82 BRD4 (0.31) MGLL
SCHEMBL6699078 0.82 MGLL (0.33) MGLL
SCHEMBL2570463 0.82 MGLL (0.33) MGLL
SCHEMBL17777287 0.82 MGLL (0.33) MGLL
SCHEMBL2610502 0.81 GLA (0.33)
SCHEMBL13348467 0.80 MAPT (0.33)
SCHEMBL12503956 0.80 TDP1 (0.31)
SCHEMBL7924643 0.80 MGLL (0.32) MGLL
SCHEMBL14898349 0.79 MGLL (0.31) MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8293869-B2 Polymer conjugates of GLP-1 NEKTAR THERAPEUTICS (US) 2012-10-23 US disclosed
US-8273339-B2 Polymer-based compositions and conjugates of antimicrobial agents NEKTAR THERAPEUTICS (US) 2012-09-25 US disclosed
US-20120195847-A1 POLYMER CONJUGATES OF BIPHALIN PEPTIDES NEKTAR THERAPEUTICS (US) 2012-08-02 US disclosed
US-20120100096-A1 CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS NEKTAR THERAPEUTICS (US) 2012-04-26 US disclosed
US-20110318322-A1 Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer NEKTAR THERAPEUTICS (US) 2011-12-29 US disclosed
US-20110237524-A1 POLYMER CONJUGATES OF AOD-LIKE PEPTIDES NEKTAR THERAPEUTICS (US) 2011-09-29 US disclosed
US-20110171164-A1 POLYMER CONJUGATES OF GLP-2-LIKE PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110171163-A1 POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110171161-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110171162-A1 POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110165112-A1 POLYMER CONJUGATES OF C-PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-07 US disclosed
US-20110135623-A1 Conjugates of a Cholinesterase Moiety and a Polymer NEKTAR THERAPEUTICS (US) 2011-06-09 US disclosed
US-20100249033-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-09-30 US disclosed
US-20100210505-A1 POLYMER CONJUGATES OF GLP-1 NEKTAR THERAPEUTICS AL, CORPORATION (US) 2010-08-19 US disclosed
US-20100160610-A1 Conjugates of an EPO Moiety and a Polymer NEKTAR THERAPEUTICS (US) 2010-06-24 US disclosed
US-20100130428-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-27 US disclosed
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-27 US disclosed
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-13 US disclosed
US-7714114-B2 Conjugates of an EPO moiety and a polymer NEKTAR THERAPEUTICS (US) 2010-05-11 US disclosed
US-7579444-B2 Polymer-factor IX moiety conjugates NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110135623-A1 Conjugates of a Cholinesterase Moiety and a Polymer BCHE, ACHE, DNPEP MGLL 497/4885
US-20110171163-A1 POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES NGLY1, VIP, IAPP MGLL 4337/4885
US-20110237524-A1 POLYMER CONJUGATES OF AOD-LIKE PEPTIDES NGLY1, OCIAD1, TAP1 MGLL 2764/4885
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES F9, F13A1, F13B MGLL 3563/4885
US-20100210505-A1 POLYMER CONJUGATES OF GLP-1 GLP1R, GIPR, NGLY1 MGLL 861/4885
US-20110165112-A1 POLYMER CONJUGATES OF C-PEPTIDES IAPP, GCG, INSR MGLL 3059/4885
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 MGLL 3516/4885
US-20110171161-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES PSMG3, PSMB11, PSMC5 MGLL 3264/4885
US-20100249033-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 MGLL 3516/4885
US-20110171162-A1 POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES TMSB4X, TMSB10, TAP1 MGLL 4633/4885
US-20120195847-A1 POLYMER CONJUGATES OF BIPHALIN PEPTIDES NGLY1, DNPEP, CIAPIN1 MGLL 3876/4885
US-20100130428-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 MGLL 3516/4885
US-20120100096-A1 CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS SLC19A1, FOLR1, SLC46A1 MGLL 4667/4885
US-20100160610-A1 Conjugates of an EPO Moiety and a Polymer EPOR, EPRS1, NPPA MGLL 4600/4885
US-20110171164-A1 POLYMER CONJUGATES OF GLP-2-LIKE PEPTIDES IAPP, GLP1R, GIPR MGLL 1103/4885
US-20110318322-A1 Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer GAA, MAN2B1, GBA1 MGLL 255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.