Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722884 | 0.89 | TSHR (0.41) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL27031985 | 0.89 | TSHR (0.41) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL6679829 | 0.84 | CTSK (0.43) | TSHRTDP1MAPTALDH1A1MAPK1 | |
| SCHEMBL2300063 | 0.82 | LTA4H (0.44) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL6683665 | 0.82 | ALDH1A1 (0.47) | TSHRTDP1ALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL1942288 | 0.81 | TSHR (0.44) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL17019229 | 0.81 | RRM1 (0.44) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL17006012 | 0.81 | RRM1 (0.44) | TSHRTDP1MAPTSLC1A3SLC1A2 | |
| SCHEMBL31470624 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL6685008 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9308274-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2016-04-12 | — | — | US | disclosed |
| US-9308274-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2016-04-12 | — | — | US | disclosed |
| US-9308274-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2014-09-11 | — | — | US | disclosed |
| US-8765883-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765883-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765883-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2014-07-01 | — | — | US | disclosed |
| EP-1827501-B2 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2013-11-20 | — | — | EP | disclosed |
| US-20110112277-A1 | Stabilized Polymeric Thiol Reagents | NEKTAR THERAPEUTICS (US) | 2011-05-12 | — | — | US | disclosed |
| EP-1827501-B1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-1827501-B1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2011-01-05 | — | — | EP | disclosed |
| US-7851565-B2 | For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs | NEKTAR THERAPEUTICS (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851565-B2 | For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs | NEKTAR THERAPEUTICS (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851565-B2 | For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs | NEKTAR THERAPEUTICS (US) | 2010-12-14 | — | — | US | disclosed |
| CN-101111267-A | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS AL CORP (US) | 2008-01-23 | — | — | CN | disclosed |
| EP-1827501-A2 | STABILIZED POLYMERIC THIOL REAGENTS | Nektar Therapeutics Al, Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006069388-A2 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135586-A1 | For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs | NEKTAR THERAPEUTICS | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112277-A1 | Stabilized Polymeric Thiol Reagents | TST, CD44, MPST | TSHR 1629/4885TDP1 2571/4885MAPT 1183/4885 |
| US-20060135586-A1 | For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs | BMX, PAM, EGFR | TSHR 818/4885TDP1 3898/4885MAPT 2512/4885 |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | TST, TTPA, MPST | TSHR 3924/4885TDP1 1695/4885MAPT 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.