SCHEMBL1020149

SCHEMBL1020149

C[Si](C)(C)CCCn1c(-c2nc3ccccc3s2)nc2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.43
TP53 P04637 4/20 0.43
LMNA P02545 5/20 0.41
KDM4E B2RXH2 5/20 0.41
HPGD P15428 4/20 0.41
TSHR P16473 4/20 0.41
ALDH1A1 P00352 4/20 0.41
HSD17B10 Q99714 3/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
MAPT P10636 3/20 0.41
MAPK1 P28482 2/20 0.41
CASP1 P29466 1/20 0.41
CXCR4 P61073 1/20 0.40
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
TLR8 Q9NR97 2/20 0.40
TNF P01375 1/20 0.40
NOD1 Q9Y239 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GAA P10253 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29979980 1.00 HTT (0.43) HTTTP53LMNAKDM4EHPGD
SCHEMBL927722 0.87 HPGD (0.39) HTTTP53LMNAKDM4EHPGD
SCHEMBL14582034 0.87 TLR8 (0.55) HTTTP53LMNAKDM4EHPGD
SCHEMBL7040964 0.76 HSD17B10 (0.64) HTTLMNAKDM4EHPGDTSHR
SCHEMBL7035923 0.75 KDM4E (0.59) HTTTP53LMNAKDM4EHPGD
SCHEMBL927859 0.73 HTT (0.44) HTTTP53LMNAKDM4EHPGD
SCHEMBL8104229 0.73 ALDH1A1 (0.42) HTTTP53LMNAKDM4EHPGD
SCHEMBL7036035 0.72 KDM4E (0.54) HTTTP53LMNAKDM4EHPGD
SCHEMBL7038401 0.71 LMNA (0.42) HTTLMNAKDM4EHPGDTSHR
SCHEMBL9331260 0.69 MAPK1 (0.53) HTTTP53LMNAKDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1028120-B1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use OREAL (FR) 2003-03-19 EP claimed
US-6221343-B1 Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof SOCIETE L'OREAL S.A. (FR) 2001-04-24 US claimed
EP-1028120-A1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use L'OREAL (FR) 2000-08-16 EP claimed
US-20230149289-A1 COSMETIC COMPOSITION FOR FORMING A FILM HAVING ELEVATED ELASTICITY AND EXTENSIBILITY COVESTRO DEUTSCHLAND AG (DE) 2023-05-18 US disclosed
US-20230135505-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS COVESTRO DEUTSCHLAND AG (DE) 2023-05-04 US disclosed
EP-4125800-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS Covestro Deutschland AG (DE) 2023-02-08 EP disclosed
CN-115209863-A Cosmetic composition for forming film with improved elasticity and extensibility 科思创德国股份有限公司 2022-10-18 CN disclosed
EP-3177267-B1 POLYURETHANEUREA SOLUTIONS FOR COSMETIC COMPOSITIONS COVESTRO DEUTSCHLAND AG (DE) 2022-01-05 EP disclosed
WO-2021198051-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS COVESTRO DEUTSCHLAND AG (DE) 2021-10-07 WO disclosed
EP-3888627-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS Covestro Deutschland AG (DE) 2021-10-06 EP disclosed
EP-3889196-A1 BIOBASED POLYURETHANE DISPERSIONS FOR SUNSCREEN APPLICATIONS Covestro Deutschland AG (DE) 2021-10-06 EP disclosed
EP-1245222-A2 Topical composition containing fibres and enzymes L'OREAL (FR) 2002-10-02 EP disclosed
EP-1243252-A1 Skin composition containing fibres and ubiquinones L'OREAL (FR) 2002-09-25 EP disclosed
EP-1243253-A1 Composition containing fibres and steroids L'OREAL (FR) 2002-09-25 EP disclosed
EP-1243254-A1 Composition containing fibres and a flavonoid L'OREAL (FR) 2002-09-25 EP disclosed
EP-1234570-A1 Cosmetic use of a matifying composition for treating greasy skin L'OREAL (FR) 2002-08-28 EP disclosed
WO-2002055046-A1 COSMETIC COMPOSITION CONTAINING MINERAL FILTERS L'OREAL (FR) 2002-07-18 WO disclosed
WO-2002043690-A1 COSMETIC COMPOSITION CONTAINING MINERAL FILTERS L'OREAL (FR) 2002-06-06 WO disclosed
US-6221343-B1 Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof SOCIETE L'OREAL S.A. (FR) 2001-04-24 US disclosed
EP-1028120-A1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use L'OREAL (FR) 2000-08-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230149289-A1 COSMETIC COMPOSITION FOR FORMING A FILM HAVING ELEVATED ELASTICITY AND EXTENSIBILITY POLR1C, CUTA, SUCLG1 HTT 382/4885TP53 3075/4885LMNA 1070/4885
US-20230135505-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS UROD, PUF60, DDT HTT 1380/4885TP53 1020/4885LMNA 2061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.