Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 6/20 | 0.52 |
| ▸ | CA2 | P00918 | 6/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484049 | 0.84 | TP53 (0.35) | CES2CES1MAPTGSK3BLMNA | |
| SCHEMBL4246590 | 0.83 | CES2 (0.55) | CES2CES1CA1CA2PARP10 | |
| SCHEMBL3802749 | 0.81 | CA1 (0.52) | CA1CA2MAPTMEN1LMNA | |
| SCHEMBL5825068 | 0.81 | KDM4E (0.41) | CES2CES1MAPTMEN1RAB9A | |
| SCHEMBL5824467 | 0.81 | PARP10 (0.54) | PARP10PLK1MAPTLMNARAB9A | |
| SCHEMBL5824521 | 0.80 | CES2 (0.59) | CES2CES1PARP1MAPTMEN1 | |
| SCHEMBL3890043 | 0.79 | CES2 (0.50) | CES2CES1CA1CA2PARP10 | |
| SCHEMBL20258185 | 0.79 | NOS3 (0.44) | MAPTLMNAMAPK1RAB9AKMT2A | |
| SCHEMBL2892447 | 0.79 | ALDH1A1 (0.48) | CES2CES1MAPTGSK3BMEN1 | |
| SCHEMBL8717053 | 0.78 | CES2 (0.64) | CES2CES1CA1CA2PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102746313-A | Rhodamine-B hydrazide derivative containing 1,2,4-triazole structural unit, preparation method and application thereof | UNIV SHANDONG | 2012-10-24 | — | — | CN | claimed |
| EP-2008530-B1 | Aroma composition for reducing or suppressing unwanted bitter and astringent impressions | SYMRISE AG (DE) | 2011-01-19 | — | — | EP | claimed |
| US-20250263368-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS THAT ARE RESISTANT TO THE HERBICIDE | PURDUE RESEARCH FOUNDATION (US) | 2025-08-21 | — | — | US | disclosed |
| US-11484529-B2 | Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production | OP2 Drugs (FR) | 2022-11-01 | — | — | US | disclosed |
| WO-2021137249-A1 | A PROCESS FOR PREPARING 2-CHLORO-N-{[4-(PYRIMIDIN-2-YLSULFAMOYL)PHENYL] CARBAMOTHIOYL} BENZAMIDE AND THE PHARMACEUTICAL UTILITY THEREOF | SOMADE PRAKASH MARUTI (IN) | 2021-07-08 | — | — | WO | disclosed |
| WO-2021137249-A1 | A PROCESS FOR PREPARING 2-CHLORO-N-{[4-(PYRIMIDIN-2-YLSULFAMOYL)PHENYL] CARBAMOTHIOYL} BENZAMIDE AND THE PHARMACEUTICAL UTILITY THEREOF | SOMADE PRAKASH MARUTI (IN) | 2021-07-08 | — | — | WO | disclosed |
| US-20210154175-A1 | DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION | OP2 Drugs (FR) | 2021-05-27 | — | — | US | disclosed |
| US-20200290959-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS THAT ARE RESISTANT TO THE HERBICIDE | PURDUE RESEARCH FOUNDATION (US) | 2020-09-17 | — | — | US | disclosed |
| WO-2019112791-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS RESISTANT TO THE HERBICIDE | PURDUE RESEARCH FOUNDATION (US) | 2019-06-13 | — | — | WO | disclosed |
| WO-2019112791-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS RESISTANT TO THE HERBICIDE | PURDUE RESEARCH FOUNDATION (US) | 2019-06-13 | — | — | WO | disclosed |
| US-9376452-B2 | Rab7 GTPase inhibitors and related methods of treatment | ST. UNM (US) | 2016-06-28 | — | — | US | disclosed |
| EP-1109790-B1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| US-20020147365-A1 | 3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same | THE FANNING CORPORATION | 2002-10-10 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-20020086862-A1 | Novel compounds | ASTRAZENECA AB | 2002-07-04 | — | — | US | disclosed |
| EP-1109790-A1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012489-A1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
| US-5001157-A | Substituted N-[[2-(aminocarbonyl)phenylamino]thioxomethyl]benzamides | AMERICAN CYANAMID COMPANY (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0157259-A1 | 3-Mercapto-1,2,4-triazacycloalcadiene derivatives | CIBA-GEIGY AG (CH) | 1985-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086862-A1 | Novel compounds | ABCG2, CYP3A4, CYP4B1 | CES2 451/4885CES1 187/4885CA1 4726/4885 |
| US-20210154175-A1 | DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION | TXN2, ROS1, ERAL1 | CES2 1845/4885CES1 650/4885CA1 4451/4885 |
| US-20250263368-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS THAT ARE RESISTANT TO THE HERBICIDE | CES2, GBA3, KLHL20 | CES2 1/4885CES1 9/4885CA1 4005/4885 |
| US-20020147365-A1 | 3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same | GPX4, LIPC, GPX1 | CES2 1376/4885CES1 433/4885CA1 4419/4885 |
| US-20200290959-A1 | CELLULOSE SYNTHASE INHIBITORS AS A NEW CLASS OF HERBICIDE AND NON-GMO CROPS THAT ARE RESISTANT TO THE HERBICIDE | CES2, EXOSC10, GBA3 | CES2 1/4885CES1 11/4885CA1 4147/4885 |
| US-11484529-B2 | Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production | TXN2, ROS1, ERAL1 | CES2 1845/4885CES1 650/4885CA1 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.