SCHEMBL10348203

SCHEMBL10348203

O=Cc1ccc(OCCS(=O)(=O)[O-])cc1.[Na+]

nearest known ligand 0.50

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA12 known ✓ O43570 2/20 0.38
CA1 known ✓ P00915 2/20 0.38
CA2 known ✓ P00918 2/20 0.38
ALDH1A1 P00352 7/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
MAPT P10636 2/20 0.50
HPGD P15428 2/20 0.50
LMNA P02545 2/20 0.50
STS P08842 1/20 0.44
CYP2A6 P11509 1/20 0.41
KDM4E B2RXH2 2/20 0.41
PTPN1 P18031 2/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 2/20 0.38
ALDH1A3 P47895 1/20 0.38
MEN1 O00255 1/20 0.38
CA7 P43166 2/20 0.38
CA9 Q16790 2/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12468573 0.87 CA12 (0.46) ALDH1A1CA12CA1CA2CA7
SCHEMBL10348204 0.79 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2MAPTHPGDLMNA
SCHEMBL851166 0.79 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2MAPTHPGDLMNA
SCHEMBL11204080 0.79 LTA4H (0.46) ALDH1A1
SCHEMBL3364128 0.78 KCNA3 (0.52) ALDH1A1KMT2AMEN1CA12CA1
SCHEMBL5583897 0.77 CA12 (0.48) ALDH1A1SMN1; SMN2LMNARAB9ACA12
SCHEMBL8551794 0.77 ALDH1A1 (0.69) ALDH1A1SMN1; SMN2MAPTHPGDLMNA
SCHEMBL5090074 0.77 ALDH1A1 (0.75) ALDH1A1SMN1; SMN2MAPTHPGDLMNA
SCHEMBL8204708 0.77 ALDH1A1 (0.75) ALDH1A1SMN1; SMN2MAPTHPGDLMNA
SCHEMBL22190236 0.76 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2MAPTHPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0223373-B1 WATER-SOLUBLE PHOTOINITIATORS AUTOTYPE INTERNATIONAL LIMITED (GB) 1990-04-18 EP disclosed
US-4824765-A DIBENZALKETONES AUTOTYPE INTERNATIONAL LIMITED, A BRITISH CO. (GB) 1989-04-25 US disclosed
EP-0223373-A1 Water-soluble photoinitiators AUTOTYPE INTERNATIONAL LIMITED (GB) 1987-05-27 EP disclosed