Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA4 | P22748 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DGKA | P23743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537574 | 0.98 | ESR2 (0.42) | ESR2PTGS2CA12CA1CA2 | |
| SCHEMBL1829919 | 0.94 | ESR2 (0.38) | ESR2PTGS2CA12CA1CA2 | |
| SCHEMBL20486280 | 0.87 | BCL9 (0.34) | ESR2PTGS2CA12CA1CA2 | |
| SCHEMBL522462 | 0.82 | KMT2A (0.43) | MEN1KMT2ADGKA | |
| SCHEMBL21049231 | 0.82 | KMT2A (0.43) | MEN1KMT2ADGKA | |
| SCHEMBL25495837 | 0.82 | KMT2A (0.43) | MEN1KMT2ADGKA | |
| SCHEMBL3539485 | 0.80 | PTGS2 (0.45) | ESR2PTGS2CA12CA1CA2 | |
| SCHEMBL4953772 | 0.80 | KMT2A (0.44) | MEN1KMT2ADGKA | |
| SCHEMBL16250391 | 0.78 | ALDH1A1 (0.36) | MEN1KMT2A | |
| SCHEMBL14152352 | 0.77 | TSHR (0.50) | ESR2PTGS2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150105547-A1 | NITRIC OXIDE RELEASING STEROIDS | NICOX S.A. (FR) | 2015-04-16 | — | — | US | disclosed |
| US-8933062-B2 | Nitric oxide releasing steroids | NICOX S.A. (FR) | 2015-01-13 | — | — | US | disclosed |
| EP-2021324-B1 | NITRATED HETEROCYCLIC COMPOUNDS AS ENDOTHELIN RECEPTOR ANTAGONIST | NICOX SA (FR) | 2011-12-14 | — | — | EP | disclosed |
| EP-2049514-B1 | NITRATE ESTERS OF PIPERIDINES | NOVARTIS AG (CH) | 2011-01-26 | — | — | EP | disclosed |
| US-20100093685-A1 | NITRIC OXIDE RELEASING STEROIDS | NICOX S.A. | 2010-04-15 | — | — | US | disclosed |
| US-20100063035-A1 | CARBONIC ANHYDRASE INHIBITORS DERIVATIVES | NICOX S.A. (FR) | 2010-03-11 | — | — | US | disclosed |
| US-20090325947-A1 | NITRATE ESTERS OF PIPERIDINES | NOVARTIS AG (CH) | 2009-12-31 | — | — | US | disclosed |
| US-20090318432-A1 | Nitrate esters of aminoalcohols | SPEEDEL EXPERIMENTA AG (CH) | 2009-12-24 | — | — | US | disclosed |
| EP-2118120-A1 | NITRIC OXIDE RELEASING STEROIDS | Nicox S.A. (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-20090263472-A1 | ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| EP-2097421-A2 | CARBONIC ANHYDRASE INHIBITORS DERIVATIVES | Nicox S.A. (FR) | 2009-09-09 | — | — | EP | disclosed |
| CN-101454283-A | Nitrated heterocyclic compounds as endothelin receptor antagonists | NICOX SA (FR) | 2009-06-10 | — | — | CN | disclosed |
| EP-2061751-A1 | NITRATE ESTERS OF AMINOALCOHOLS | Novartis Ag (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-2049514-A1 | NITRATE ESTERS OF PIPERIDINES | Speedel Experimenta AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| EP-2021324-A1 | NITRATED HETEROCYCLIC COMPOUNDS AS ENDOTHELIN RECEPTOR ANTAGONIST | NicOx S.A. (FR) | 2009-02-11 | — | — | EP | disclosed |
| WO-2008095806-A1 | NITRIC OXIDE RELEASING STEROIDS | NICOX S.A. (FR) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008075155-A2 | CARBONIC ANHYDRASE INHIBITORS DERIVATIVES | NICOX S.A. (FR) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008031811-A1 | NITRATE ESTERS OF AMINOALCOHOLS | SPEEDEL EXPERIMENTA AG (CH) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008017685-A1 | NITRATE ESTERS OF PIPERIDINES | SPEEDEL EXPERIMENTA AG (CH) | 2008-02-14 | — | — | WO | disclosed |
| WO-2007137980-A1 | NITRATED HETEROCYCLIC COMPOUNDS AS ENDOTHELIN RECEPTOR ANTAGONIST | NICOX S.A. (FR) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105547-A1 | NITRIC OXIDE RELEASING STEROIDS | NR3C1, CYP11B1, NOS1 | ESR2 212/4885PTGS2 121/4885CA12 2683/4885 |
| US-20090263472-A1 | ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES | EDNRA, EDNRB, ECE1 | ESR2 26/4885PTGS2 102/4885CA12 4780/4885 |
| US-20100063035-A1 | CARBONIC ANHYDRASE INHIBITORS DERIVATIVES | CA4, CA2, CA9 | ESR2 4146/4885PTGS2 129/4885CA12 33/4885 |
| US-20090318432-A1 | Nitrate esters of aminoalcohols | NOS2, NOS1, NOS3 | ESR2 1974/4885PTGS2 428/4885CA12 3887/4885 |
| US-20100093685-A1 | NITRIC OXIDE RELEASING STEROIDS | NR3C1, CYP11B1, NOS1 | ESR2 245/4885PTGS2 185/4885CA12 2504/4885 |
| US-20090325947-A1 | NITRATE ESTERS OF PIPERIDINES | NOS2, NOS1, NOS3 | ESR2 1612/4885PTGS2 115/4885CA12 4814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.