Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437625 | 1.00 | PKM (0.50) | PKMADRB2ADRB1TP53MAPT | |
| SCHEMBL13654852 | 1.00 | PKM (0.50) | PKMADRB2ADRB1TP53MAPT | |
| SCHEMBL11025742 | 0.88 | MGLL (0.48) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL32685172 | 0.87 | MGLL (0.52) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL8537272 | 0.86 | CYP4F2 (0.55) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL9628772 | 0.86 | PKM (0.52) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL6016764 | 0.86 | PKM (0.52) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL11021516 | 0.85 | ALDH1A1 (0.46) | PKMADRB2ADRB1TP53MAPT | |
| SCHEMBL32685184 | 0.85 | MGLL (0.50) | PKMTP53MAPTHPGDTSHR | |
| SCHEMBL10840789 | 0.84 | LMNA (0.53) | PKMTP53MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651706-A | Preparation process of high-purity esmolol hydrochloride | 湖州展望药业有限公司 | 2021-11-16 | — | — | CN | claimed |
| CN-119613359-A | Preparation of esmolol hydrochloride key intermediate | 广东京豪生物制药有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-119613358-A | Preparation process of esmolol hydrochloride | 广东京豪生物制药有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-113651706-A | Preparation process of high-purity esmolol hydrochloride | 湖州展望药业有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-113651706-A | Preparation process of high-purity esmolol hydrochloride | 湖州展望药业有限公司 | 2021-11-16 | — | — | CN | disclosed |
| US-20210154202-A1 | SYNTHESIS OF DENTIMOL, AN ANTIGLAUCOMA DRUG | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| US-20130302245-A1 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130302245-A1 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130302245-A1 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-11-14 | — | — | US | disclosed |
| US-8440168-B2 | Image-guided therapy of myocardial disease: composition, manufacturing and applications | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-14 | — | — | US | disclosed |
| US-4387103-A | SHORT ACTING BETA BLOCKING AGENTS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1983-06-07 | — | — | US | disclosed |
| WO-1983001772-A1 | ESTERS OF ARYLOXYPROPANOLAMINE DERIVATIVES AND USE AS 'beta'-ADRENERGIC BLOCKING AGENTS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-05-26 | — | — | WO | disclosed |
| EP-0065542-A4 | COMPOUNDS SUITABLE FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-04-25 | — | — | EP | disclosed |
| EP-0065963-A4 | COMPOUNDS AND METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-04-25 | — | — | EP | disclosed |
| EP-0065963-A1 | COMPOUNDS AND METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-12-08 | — | — | EP | disclosed |
| EP-0065542-A1 | COMPOUNDS SUITABLE FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-12-01 | — | — | EP | disclosed |
| WO-1982001870-A1 | COMPOUNDS AND METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-06-10 | — | — | WO | disclosed |
| WO-1982001869-A1 | METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-06-10 | — | — | WO | disclosed |
| EP-0053435-A1 | Compounds suitable for treatment or prophylaxis of cardiac disorders | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1982-06-09 | — | — | EP | disclosed |
| EP-0053434-A1 | Compounds and method for treatment or prophylaxis of cardiac disorders | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1982-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130302245-A1 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS | ADRB1, ADRB3, ADRB2 | PKM 2292/4885ADRB2 3/4885ADRB1 1/4885 |
| US-20210154202-A1 | SYNTHESIS OF DENTIMOL, AN ANTIGLAUCOMA DRUG | PTGIR, PTGIS, DNM1L | PKM 719/4885ADRB2 22/4885ADRB1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.