SCHEMBL10602000

SCHEMBL10602000

O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(OP(=O)([O-])[O-])c12.[Na+].[Na+]

nearest known ligand 0.64

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRP known ✓ O00591 3/20 0.64
GABRD known ✓ O14764 3/20 0.64
GABRA1 known ✓ P14867 3/20 0.64
GABRB1 known ✓ P18505 3/20 0.64
GABRG2 known ✓ P18507 3/20 0.64
GABRB3 known ✓ P28472 3/20 0.64
GABRA5 known ✓ P31644 3/20 0.64
GABRA3 known ✓ P34903 3/20 0.64
GABRA2 known ✓ P47869 3/20 0.64
GABRB2 known ✓ P47870 3/20 0.64
GABRA4 known ✓ P48169 3/20 0.64
GABRE known ✓ P78334 3/20 0.64
GABRA6 known ✓ Q16445 3/20 0.64
GABRG1 known ✓ Q8N1C3 3/20 0.64
GABRG3 known ✓ Q99928 3/20 0.64
GABRQ known ✓ Q9UN88 3/20 0.64
XDH known ✓ P47989 2/20 0.64
NR3C1 known ✓ P04150 1/20 0.64
THRB known ✓ P10828 1/20 0.64
CA12 known ✓ O43570 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL737652 0.91 CREB1 (0.70) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL10517788 0.89 ABCB1 (0.66) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL11094925 0.88 ABCB1 (0.64) ABCB1CREB1MAPTCYP3A4CYP1A1
Baicalein SCHEMBL11094929 0.85 ABCB1 (0.84) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL17663637 0.83 CREB1 (0.81) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL22966703 0.81 ABCB1 (0.60) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL22966699 0.80 CREB1 (0.82) ABCB1CREB1MAPTCYP3A4CYP1A1
SCHEMBL22966701 0.80 ABCB1 (0.66) ABCB1CREB1MAPTCYP3A4CYP1A1
Baicalein SCHEMBL5695785 0.79 ABCB1 (1.00) ABCB1CREB1MAPTCYP3A4CYP1A1
Baicalein SCHEMBL29385549 0.79 ABCB1 (1.00) ABCB1CREB1MAPTCYP3A4CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0038674-B1 MEDICINAL COMPOSITION FOR TREATMENT OF ALLERGIC DISEASES Takeda Chemical Industries, Ltd. (JP) 1989-08-30 EP disclosed
US-4358461-A Antiallergic agent TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1982-11-09 US disclosed
EP-0038674-A1 Medicinal composition for treatment of allergic diseases Takeda Chemical Industries, Ltd. (JP) 1981-10-28 EP disclosed