Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680630 | 0.87 | NPC1 (0.34) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10681969 | 0.85 | MAPT (0.47) | MAPTCDC7UCHL1RAB9AL3MBTL1 | |
| SCHEMBL10679912 | 0.84 | CDC7 (0.40) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10683554 | 0.83 | UCHL1 (0.43) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7380127 | 0.81 | PDE3B (0.46) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10676997 | 0.80 | ALDH1A1 (0.53) | MAPTRAB9AL3MBTL1LMNANPC1 | |
| SCHEMBL10680827 | 0.77 | RAB9A (0.35) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10675823 | 0.75 | CDC7 (0.38) | MAPTCDC7UCHL1RAB9APDE3B | |
| SCHEMBL10677717 | 0.71 | ALDH1A1 (0.44) | MAPTUCHL1RAB9APDE3BPDE3A | |
| SCHEMBL10682462 | 0.71 | MAPT (0.53) | MAPTUCHL1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |