Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716446 | 0.75 | MAPT (0.50) | MAPTALDH1A1KDM4EPTGS2CYP2C9 | |
| SCHEMBL10730384 | 0.74 | MAPT (0.56) | MAPTALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL14960618 | 0.74 | SLC40A1 (0.52) | ALDH1A1PTGS2PTGS1PTGES2SLC22A12 | |
| SCHEMBL10730881 | 0.73 | MAPT (0.54) | MAPTALDH1A1KDM4EPTGS2CYP2C9 | |
| SCHEMBL10730622 | 0.72 | MAPT (0.57) | MAPTALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL10716377 | 0.72 | MAPT (0.56) | MAPTALDH1A1KDM4EPTGS2PKM | |
| SCHEMBL10716583 | 0.72 | MAPT (0.56) | MAPTALDH1A1KDM4EL3MBTL1PTGS2 | |
| SCHEMBL10726134 | 0.71 | MAPT (0.49) | MAPTALDH1A1KDM4EPKMLMNA | |
| SCHEMBL10716650 | 0.71 | MAPT (0.78) | MAPTALDH1A1PKMLMNAHPGD | |
| SCHEMBL10717891 | 0.71 | MAPT (1.00) | MAPTALDH1A1L3MBTL1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | claimed |
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | disclosed |