SCHEMBL108260

SCHEMBL108260

COc1c(C)cc(NCCO)cc1NCCO

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
BMPR1B O00238 1/20 0.38
STK16 O75716 1/20 0.38
ABL1 P00519 1/20 0.38
FLT3 P36888 1/20 0.38
MAPK8 P45983 1/20 0.38
MAPK9 P45984 1/20 0.38
MAPK10 P53779 1/20 0.38
DMPK Q09013 1/20 0.38
MAP2K5 Q13163 1/20 0.38
KDM4E B2RXH2 3/20 0.37
GLA P06280 2/20 0.37
GAA P10253 4/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
MAPK1 P28482 2/20 0.35
HTT P42858 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
NPC1 O15118 2/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4637282 0.90 ALDH1A1 (0.51) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL3115134 0.90 KDM4E (0.40) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL15058572 0.87 ALDH1A1 (0.38) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL5550162 0.85 ALDH1A1 (0.36) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL6258436 0.83 ALDH1A1 (0.38) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL15058573 0.82 CTSL (0.31) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL111335 0.79 KDM4E (0.41) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL109784 0.79 ALDH1A1 (0.47) ALDH1A1KDM4EGLAGAAKMT2A
SCHEMBL5176527 0.79 KDM4E (0.41) ALDH1A1BMPR1BSTK16ABL1FLT3
SCHEMBL19326793 0.77 ALDH1A1 (0.37) ALDH1A1BMPR1BSTK16ABL1FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12178897-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations HENKEL AG & CO. KGAA (DE) 2024-12-31 US claimed
US-12109291-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations HENKEL AG & CO. KGAA (DE) 2024-10-08 US claimed
US-12102704-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations HENKEL AG & CO. KGAA (DE) 2024-10-01 US claimed
US-12097274-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations HENKEL AG & CO. KGAA (DE) 2024-09-24 US claimed
US-11918671-B2 Multi-tone hair dyeing method in three steps HENKEL AG & CO. KGAA (DE) 2024-03-05 US claimed
US-20230310296-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations HENKEL AG & CO. KGAA (DE) 2023-10-05 US claimed
WO-2023163908-A1 OXIDATIVE DYEING AGENT FOR KERATIN FIBERS COMPRISING NOVEL DYE PRECURSOR COMBINATIONS HENKEL AG & CO. KGAA (DE) 2023-08-31 WO claimed
US-20230270649-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations HENKEL AG & CO. KGAA (DE) 2023-08-31 US claimed
WO-2023163907-A1 OXIDATIVE DYEING AGENT FOR KERATIN FIBERS COMPRISING NOVEL DYE PRECURSOR COMBINATIONS HENKEL AG & CO. KGAA (DE) 2023-08-31 WO claimed
US-20230270647-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations HENKEL AG & CO. KGAA (DE) 2023-08-31 US claimed
EP-1726289-A2 Dyeing composition for keratin fibres which contains a reducing agent Henkel Kommanditgesellschaft auf Aktien (DE) 2006-11-29 EP claimed
WO-2006108505-A2 OXIDATION DYES COMPRISING 2-FURANONES AND COLLAGEN (DERIVATIVES) HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-10-19 WO claimed
EP-1707242-A1 Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent Henkel Kommanditgesellschaft auf Aktien (DE) 2006-10-04 EP claimed
WO-2006048069-A1 OXIDATION DYE WITHOUT A DEVELOPER COMPONENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-05-11 WO claimed
EP-1629824-A1 New coupler components Henkel Kommanditgesellschaft auf Aktien (DE) 2006-03-01 EP claimed
WO-2006018089-A1 OXIDATION COLORANTS COMPRISING DIAMINOBENZENE DERIVATIVES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-02-23 WO claimed
US-20060000032-A1 Novel coupling components HENKEL AG & CO. KGAA (DE) 2006-01-05 US claimed
EP-1517669-B1 NOVEL COUPLING COMPONENTS HENKEL KGAA (DE) 2005-10-26 EP claimed
EP-1517669-A1 NOVEL COUPLING COMPONENTS Henkel Kommanditgesellschaft auf Aktien (DE) 2005-03-30 EP claimed
WO-2004058204-A1 NOVEL COUPLING COMPONENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-07-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12109291-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations KRT18, ALDH5A1, ALDH2 ALDH1A1 40/4885BMPR1B 2692/4885STK16 3039/4885
US-20230270647-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations KRT18, ALDH5A1, COX5A ALDH1A1 28/4885BMPR1B 2338/4885STK16 2554/4885
US-11918671-B2 Multi-tone hair dyeing method in three steps TYR, HAO2, HAAO ALDH1A1 111/4885BMPR1B 1082/4885STK16 4560/4885
US-20230270649-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations KRT18, ALDH5A1, COX5A ALDH1A1 37/4885BMPR1B 2670/4885STK16 2139/4885
US-20060000032-A1 Novel coupling components KRT18, C9, H1-4 ALDH1A1 450/4885BMPR1B 510/4885STK16 2544/4885
US-12102704-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations KRT18, ALDH5A1, ALDH2 ALDH1A1 26/4885BMPR1B 2191/4885STK16 2894/4885
US-12097274-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations KRT18, ALDH5A1, COX5A ALDH1A1 28/4885BMPR1B 2338/4885STK16 2554/4885
US-20230310296-A1 Oxidative Dyeing Agent For Keratin Fibers Comprising Novel Dye Precursor Combinations KRT18, ALDH5A1, ALDH2 ALDH1A1 40/4885BMPR1B 2692/4885STK16 3039/4885
US-12178897-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations KRT18, ALDH5A1, COX5A ALDH1A1 37/4885BMPR1B 2670/4885STK16 2139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.