Sugi Predict

Sugi Predict / Compounds / SCHEMBL1095186

SCHEMBL1095186

SCHEMBL1095186

NNC(=O)c1cc(Cl)ccc1N

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.70
▸ KDM4E B2RXH2 4/20 0.65
▸ MAPT P10636 3/20 0.65
▸ FADS1 O60427 2/20 0.61
▸ RECQL P46063 1/20 0.54
▸ GCK P35557 2/20 0.54
▸ LMNA P02545 1/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ NOS2 P35228 2/20 0.50
▸ RAB9A P51151 2/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ GFER P55789 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ ABL1 P00519 1/20 0.47
▸ ALPL P05186 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3637360 0.85 FADS1 (0.61) ALDH1A1KDM4EMAPTFADS1RECQL
SCHEMBL10705838 0.85 KDM4E (0.70) ALDH1A1KDM4EMAPTFADS1RECQL
SCHEMBL10560904 0.84 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTRECQLLMNA
SCHEMBL140037 0.83 FADS1 (0.59) ALDH1A1KDM4EFADS1RECQLGCK
SCHEMBL1127910 0.82 ALDH1A1 (1.00) ALDH1A1KDM4EMAPTLMNAL3MBTL1
SCHEMBL11689255 0.82 NOS2 (0.63) ALDH1A1FADS1RECQLGCKLMNA
SCHEMBL15503392 0.82 RECQL (0.59) ALDH1A1KDM4EMAPTFADS1RECQL
SCHEMBL10705234 0.81 CDK1 (0.57) ALDH1A1FADS1RECQLGCKL3MBTL1
SCHEMBL9048413 0.81 FADS1 (0.54) ALDH1A1KDM4EMAPTFADS1RECQL
SCHEMBL3277584 0.81 ALDH1A1 (0.70) ALDH1A1KDM4EMAPTLMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220017524-A1 ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS THE BROAD INSTITUTE, INC. (US) 2022-01-20 — — US disclosed
EP-2591354-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2016-09-07 — — EP disclosed
EP-2591354-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2016-09-07 — — EP disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 — — US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 — — US disclosed
US-8481579-B2 Triazolyl phenyl benzenesulfonamides CHEMOCENTRYX, INC. (US) 2013-07-09 — — US disclosed
US-20120165303-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CHEMOCENTRYX, INC. (US) 2012-06-28 — — US disclosed
US-8153818-B2 Triazolyl phenyl benzenesulfonamides CHEMOCENTRYX, INC. (US) 2012-04-10 — — US disclosed
EP-2046762-B1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CHEMOCENTRYX INC (US) 2011-02-16 — — EP disclosed
US-20100190762-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CHEMOCENTRYX, INC. (US) 2010-07-29 — — US disclosed
US-7718683-B2 Triazolyl phenyl benzenesulfonamides CHEMOCENTRYX, INC. (US) 2010-05-18 — — US disclosed
EP-2046762-A2 TRIAZOLYL PHENYL BENZENESULFONAMIDES ChemoCentryx Inc (US) 2009-04-15 — — EP disclosed
US-20080039465-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CHEMOCENTRYX, INC. 2008-02-14 — — US disclosed
WO-2008010934-A2 TRIAZOLYL PHENYL BENZENESULFONAMIDES CHEMOCENTRYX, INC. (US) 2008-01-24 — — WO disclosed
US-20040110963-A1 Novel hydrazones ARPIDA AG (CH) 2004-06-10 — — US disclosed
EP-1404644-A2 NOVEL HYDRAZONES Arpida AG, (CH) 2004-04-07 — — EP disclosed
WO-2002070464-A2 HYDRAZONES AND THEIR THERAPEUTIC USE ARPIDA AG (CH) 2002-09-12 — — WO disclosed
US-4713383-A ADENOSINE AND BENZODIAZEPINE ANTAGONISTS CIBA-GEIGY CORPORATION (US) 1987-12-15 — — US disclosed
US-4642322-A Stabilization of chlorine-containing thermoplastics with nitrogen-containing organic compounds CIBA-GEIGY CORPORATION (US) 1987-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120165303-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CCR9, CCR2, CCR1 ALDH1A1 2935/4885KDM4E 3642/4885MAPT 3653/4885
US-20100190762-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CCR9, CCR2, CCR1 ALDH1A1 2935/4885KDM4E 3642/4885MAPT 3653/4885
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC10A2, SLC34A2, SLC34A3 ALDH1A1 3332/4885KDM4E 4411/4885MAPT 3270/4885
US-20040110963-A1 Novel hydrazones H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HK1, MPO ALDH1A1 956/4885KDM4E 3228/4885MAPT 3140/4885
US-20220017524-A1 ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS AHR, ESRRA, AR ALDH1A1 395/4885KDM4E 2990/4885MAPT 4841/4885
US-20080039465-A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES CCR9, CCR2, CCR1 ALDH1A1 2935/4885KDM4E 3642/4885MAPT 3653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.