SCHEMBL1097922

SCHEMBL1097922

CCCC(F)(F)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
ALDH1A1 P00352 1/20 0.46
KCNN4 O15554 3/20 0.41
SCN1A P35498 3/20 0.38
SCN2A Q99250 3/20 0.38
SCN3A Q9NY46 3/20 0.38
TAAR1 Q96RJ0 1/20 0.38
DAO P14920 1/20 0.37
PTPN1 P18031 1/20 0.37
MAPK1 P28482 1/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
NFKB1 P19838 1/20 0.36
CYP2C19 P33261 1/20 0.36
MTOR P42345 1/20 0.36
RAB9A P51151 1/20 0.36
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12409056 0.86 ALDH1A1 (0.42) TSHRALDH1A1KCNN4TAAR1DAO
SCHEMBL16933755 0.85 ALDH1A1 (0.41) TSHRALDH1A1KCNN4SIGMAR1KIF11
SCHEMBL2323605 0.83 SIGMAR1 (0.40) TSHRALDH1A1MAPK1SIGMAR1SMN1; SMN2
SCHEMBL20636787 0.83 SIGMAR1 (0.40) TSHRALDH1A1MAPK1SIGMAR1SMN1; SMN2
SCHEMBL16933716 0.83 SIGMAR1 (0.40) TSHRALDH1A1MAPK1SIGMAR1SMN1; SMN2
SCHEMBL13440 0.80 TSHR (0.50) TSHRALDH1A1KCNN4TAAR1DAO
SCHEMBL25801667 0.77 CA1 (0.39) TSHRALDH1A1ESR1ESR2CA1
SCHEMBL3724473 0.77 ESR1 (0.38) ESR1ESR2
SCHEMBL10846553 0.77 ALDH1A1 (0.42) TSHRALDH1A1KCNN4PTPN1LMNA
SCHEMBL15302861 0.77 TSHR (0.42) TSHRALDH1A1KCNN4SCN1ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3527600-B1 ISOCYANATE COMPOSITION AND PRODUCTION METHOD FOR ISOCYANATE POLYMER ASAHI CHEMICAL IND (JP) 2025-07-09 EP disclosed
US-20230114799-A1 ISOCYANATE COMPOSITION AND METHOD FOR PRODUCING ISOCYANATE POLYMER ASAHI KASEI KABUSHIKI KAISHA (JP) 2023-04-13 US disclosed
US-11548975-B2 Isocyanate composition and method for producing isocyanate polymer ASAHI KASEI KABUSHIKI KAISHA (JP) 2023-01-10 US disclosed
CN-108484361-B (S) -4-chloro-1- (2,5) -difluorophenylbutan-1-ol and preparation method and application thereof 弈柯莱生物科技(上海)股份有限公司 2022-09-30 CN disclosed
CN-108484361-B (S) -4-chloro-1- (2,5) -difluorophenylbutan-1-ol and preparation method and application thereof 弈柯莱生物科技(上海)股份有限公司 2022-09-30 CN disclosed
WO-2022192598-A1 HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES INC. (US) 2022-09-15 WO disclosed
CN-109803992-B Isocyanate composition and method for producing isocyanate polymer 旭化成株式会社 2022-05-24 CN disclosed
CN-109843963-B Isocyanate composition, method for producing isocyanate polymer, and isocyanate polymer 旭化成株式会社 2022-05-13 CN disclosed
EP-3925945-A1 METHOD FOR PRODUCING FLUORINATED COMPOUND Daikin Industries, Ltd. (JP) 2021-12-22 EP disclosed
EP-3536683-B1 POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION ASAHI CHEMICAL IND (JP) 2021-11-24 EP disclosed
US-10301417-B2 Polyisocyanate composition and isocyanate polymer composition ASAHI KASEI KABUSHIKI KAISHA (JP) 2019-05-28 US disclosed
US-20190071376-A1 METHOD FOR PRODUCING FLUORINATED COMPOUND DAIKIN INDUSTRIES, LTD. (JP) 2019-03-07 US disclosed
EP-3428145-A1 METHOD FOR PRODUCING FLUORINATED COMPOUND Daikin Industries, Ltd. (JP) 2019-01-16 EP disclosed
US-10125212-B2 Polyisocyanate composition and isocyanate polymer composition ASAHI KASEI KABUSHIKI KAISHA (JP) 2018-11-13 US disclosed
EP-3372579-A1 POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION Asahi Kasei Kabushiki Kaisha (JP) 2018-09-12 EP disclosed
US-20170298169-A1 Polyisocyanate Composition and Isocyanate Polymer Composition ASAHI KASEI KABUSHIKI KAISHA (JP) 2017-10-19 US disclosed
EP-2915803-A1 POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION Asahi Kasei Chemicals Corporation (JP) 2015-09-09 EP disclosed
US-20150210631-A1 Polyisocyanate Composition and Isocyanate Polymer Composition ASAHI KASEI CHEMICALS CORPORATION (JP) 2015-07-30 US disclosed
US-8153682-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2012-04-10 US disclosed
US-20110294813-A1 OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 SHIONOGI & CO., LTD. (JP) 2011-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10301417-B2 Polyisocyanate composition and isocyanate polymer composition PAH, ALKBH1, ALKBH3 TSHR 4682/4885ALDH1A1 427/4885KCNN4 397/4885
US-11548975-B2 Isocyanate composition and method for producing isocyanate polymer IDH3A, IDH2, IDH3B TSHR 4885/4885ALDH1A1 643/4885KCNN4 810/4885
US-20110294813-A1 OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 HSD17B3, HSD17B1, HSD3B1 TSHR 2273/4885ALDH1A1 113/4885KCNN4 3321/4885
US-20170298169-A1 Polyisocyanate Composition and Isocyanate Polymer Composition TST, SUDS3, SCLY TSHR 4448/4885ALDH1A1 2991/4885KCNN4 384/4885
US-20230114799-A1 ISOCYANATE COMPOSITION AND METHOD FOR PRODUCING ISOCYANATE POLYMER IDH3A, IDH2, IDH3B TSHR 4885/4885ALDH1A1 666/4885KCNN4 1178/4885
US-10125212-B2 Polyisocyanate composition and isocyanate polymer composition TST, SUDS3, SCLY TSHR 4448/4885ALDH1A1 2991/4885KCNN4 384/4885
US-20190071376-A1 METHOD FOR PRODUCING FLUORINATED COMPOUND RXFP2, BLVRB, AFF2 TSHR 172/4885ALDH1A1 1416/4885KCNN4 3708/4885
US-20150210631-A1 Polyisocyanate Composition and Isocyanate Polymer Composition TST, SUDS3, SCLY TSHR 4448/4885ALDH1A1 2991/4885KCNN4 384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.