Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.51 |
| ▸ | PNMT | P11086 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870205 | 0.93 | PNMT (0.54) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL10229556 | 0.90 | TDP2 (0.49) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL467503 | 0.89 | PNMT (0.57) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL1785799 | 0.87 | TDP2 (0.56) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL14061819 | 0.87 | CYP1A2 (0.51) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL9483063 | 0.85 | PNMT (0.65) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL30709850 | 0.85 | PNMT (0.65) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL5145572 | 0.83 | PNMT (0.51) | TDP2PNMTKMT2AADRA2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL27905491 | 0.79 | LMNA (0.62) | TDP2PNMTKMT2AADRA2AMEN1 | |
| SCHEMBL1715396 | 0.77 | PNMT (0.61) | TDP2PNMTKMT2AADRA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117412971-A | Pyrrolopyrimidine derivatives containing pyrazine structures | 微境生物医药科技(上海)有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117222649-A | Pyrrolopyrimidine derivatives, process for their preparation and their use | 微境生物医药科技(上海)有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-116848118-A | Pyrazolo [3,4-d ] pyrimidin-3-one derivatives as Wee-1 inhibitors | 微境生物医药科技(上海)有限公司 | 2023-10-03 | — | — | CN | disclosed |
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-04-27 | — | — | US | disclosed |
| WO-2022237844-A1 | PYRROLOPYRIMIDINE DERIVATIVE CONTAINING PYRAZINE STRUCTURE | 微境生物医药科技(上海)有限公司 | 2022-11-17 | — | — | WO | disclosed |
| US-9587266-B2 | Mutant luciferases | UNIVERSITY OF MASSACHUSETTS (US) | 2017-03-07 | — | — | US | disclosed |
| US-9321750-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-10-08 | — | — | US | disclosed |
| US-8153410-B2 | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules | FOX CHASE CANCER CENTER (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153410-B2 | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules | FOX CHASE CANCER CENTER (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153410-B2 | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules | FOX CHASE CANCER CENTER (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | FOX CHASE CANCER CENTER (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | FOX CHASE CANCER CENTER (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | FOX CHASE CANCER CENTER (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | RORA, RORB, RORC | TDP2 4783/4885PNMT 2818/4885KMT2A 677/4885 |
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | BMP2, BMP1, MYOF | TDP2 3764/4885PNMT 3934/4885KMT2A 4620/4885 |
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PAH, ALDH2, IDH2 | TDP2 1898/4885PNMT 1641/4885KMT2A 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.